关键词: 胃肠间质瘤, 复发, 转移, 靶向治疗, 手术治疗

Abstract:

Role of surgery in treatment of recurrent or metastatic gastrointestinal stromal tumor        WANG Ya-nong, ZHOU Ye. Department of Gastric and Soft Tissue Surgery, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China
Corresponding author: WANG Ya-nong, E-mail: wang_yn_ch@163.com
Abstract    Gastrointestinal stromal tumor (GIST) is the most common soft tissue sarcomas of the gastrointestinal tract. With the understanding of the mechanisms of GIST carcinogenesis, tyrosine kinase inhibitors (TKIs) have greatly improved the prognosis of patients with recurrent or metastatic GIST, compared to traditional surgery. However, 5% of complete response and gradually appearance of secondary tumor resistance to TKIs still encourage surgeons to evaluate the effect of TKIs combined with surgery. Surgical cytoreduction in patients with recurrent or metastatic GISTs in era of target therapy is the hot spot. The surgery in highly selected patients who have good response to TKIs should be considered fully in the multidisciplinary treatment.

Key words: gastrointestinal stromal tumor, recurrence, metastasis, target therapy, surgery