关键词: 胃肠胰神经内分泌肿瘤, 病理诊断

Abstract:

Consensus and controversy of pathological diagnosis of gastrointestinal and pancreatic neuroendocrine neoplasms        SHENG Wei-qi. Department of Pathology，Fudan University Shanghai Cancer Center，Shanghai 200032，China
Abstract    Revised classification, nomenclature and grading system of gastroenteropancreatic neuroendocrine neoplas (GEP-NENs) was proposed by the fourth edition World Health Organization Classification of Tumours of the Digestive System in 2010. Chinese Consensus of Pathological Diagnosis of Gastroenteropancreatic Neuroendocrine Neoplasm (hereinafter referred to as Chinese Consensus ) was issued in 2011. It apparently contributes to unify the methods of classification，put an end of the confusion in nomenclature, standardize the grading system and predict the outcomes more accurately. Recently, new advances in GEP-NENs study put forward a new view in the classification and grading system that leading to several controversies. Consequently, an update of Chinese Consensus was published in 2013. It not only emphasized the key points of pathological diagnosis of GEP-NENs, expanded the content of morphological description and the methods of proliferation index evaluation, but also made its own suggestions aimed at the pending problem. However, the update of system needs further studies.

Key words: gastroenteropancreatic neuroendocrine neoplasm, pathological diagnosis