关键词: 乳腺癌, 代谢, 微环境, 耐药, 转移

Abstract: The latest trends and development direction of breast cancer basic research        JIN Ying, LIU Zhen-yu, GAO Pin，et al. Department of Breast Surgery, the First Bethune Hospital of Jilin University, Changchun 130021, China
Corresponding author：FAN Zhi-min, E-mail: fanzm@jlu.edu.cn
Abstract    Breast cancer is the most frequently diagnosed cancer among women，and its research progress has been widely concerned.The accumulated basic research results provide a theoretical basis for earlier detection，more accurate treatment and better prognosis.During tumorigenesis，breast cancer cells undergo metabolic reprogramming.However，the extension and functional importance of these metabolic alterations may diverge according to breast cancer subtypes.Meanwhile，cancer cells interact with the surrounding complex microenvironment，and the changes of metabolism and microenvironment further affect the therapeutic effect of tumor drugs and distant metastasis.

Key words: breast cancer, metabolism, microenvironment, drug resistance, metastasis