关键词: 直肠癌前切除术, 吻合口漏, 危险因素

Abstract:

Risk factors for anastomotic leakage after anterior resection for rectal cancer        PAN Bo，ZHOU Jian-ping，DONG Ming. Department of Gastrointestinal Surgery，the First Hospital of China Medical University，Shenyang 110001，China
Corresponding author：DONG Ming，E-mail：dongming@cmu.edu.cn
Abstract    Objective    To explore the risk factors for anastomotic leakage after anterior resection for rectal cancer. Methods    The clinical data of 262 patients who underwent anterior resection for rectal cancer in the Department of Gastrointestinal Surgery, the First Hospital to China Medical University from January 2014 to June 2018 were analyzed retrospectively. The association between the 31 variables and anastomotic leakage by univariate and multivariate logistic regression analyses were performed. Results    Forty-one patients had anastomotic leakage which constituted 15.6% of total 262 patients who underwent anterior resection for rectal cancer. The results of univariate analyses revealed that：the number of distal rectal cut closure（P=0.040），anastomotic methods（P=0.030），perioperative blood transfusion（P<0.001），postoperative diarrhea（P<0.001） were significantly associated with anastomotic leakage; Multivariate analyses found that: anastomotic methods（P=0.008），perioperative blood transfusion（P<0.001），postoperative diarrhea（P<0.001） were significantly associated with anastomotic leakage independently. Conclusion    In anterior resection of rectal cancer，reduce use frequency  of anastomat stapler，avoid unnecessary perioperative blood transfusion，and pay attention to early postoperative diarrhea，it is helpful to reduce anastomotic leakage.

Key words: anterior resection for rectal cancer, anastomotic leakage, risk factor