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01 January 2009, Volume 29 Issue 1 Previous Issue    Next Issue

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null HU Da-yi,WANG Jia-hong 2009, 29(1): 2-4.  Abstract ( )   PDF (296KB) ( )   null

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Clinical strategy and application on intensive lipid-lowering treatment ZHAO Shui-ping 2009, 29(1): 5.  Abstract ( )   PDF (300KB) ( )   The massive researches confirmed intensive lipidlowering therapy can block or reverse the progress of atherosclerosis.At present it has been believed that the term of intensive therapy should remain at least for 2 years in the patients with acute coronary syndrome.Significant reduction in the cholesterol is also essential for the patients with stable coronary heart disease.It should be realized that markedly lowering the cholesterol has latent damage and limitation.Lower lipid level does not mean better status.The adverse effects are also need to be monitored simultaneously.

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Clinical evaluation of different types of lipid-lowering Medicine ZHANG Dong-wei,WANG Hai-chang 2009, 29(1): 7.  Abstract ( )   PDF (307KB) ( )   The article mainly makes an outline on five kinds of lipid-regulating drugs (except for statins) and their combined application.The fibrates is suitable for hypertriglyceridemia,mixed hyperlipemia (triglyceride increases more) and low high-density lipoprotein-cholesterinemia.Up to now,nicotinamide acid is known as the most effective drug for elevating HDL.Statins combined with cholic acid chelating agent or fish oil agent n-3 fatty acid has a good cooperative effect on lowering serum lipid.

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Clinical practice of traditional chinese medicine on lipid-regulation ZHANG Jing-chun 2009, 29(1): 10.  Abstract ( )   PDF (292KB) ( )   The traditional Chinese medicines come from natural and include many kinds of active ingredients.The clinical and experimental studies indicate that some traditional Chinese medicines (including the compound and the monomer) may regulate the lipid on multitargets in vivo,which has certain value in only research and application.Present clinical researches on traditional Chinese medicines for lipidregulation are limited in only regulating biochemistry level,small samples,poor repeatability,short of multicentral largesample randomcontrol experiments and absence of long term followup on cardiovascular and cerebrovascular adverse events.We should take the advantage of traditional Chinese medicine superiority in lipidregulating process by scientific researches.

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New theory and new practice of Statins in the management of ischemic stroke WANG Chun-xue,WANG Yong-jun 2009, 29(1): 12.  Abstract ( )   PDF (291KB) ( )   Nowadays,statin has been one of the key medications for the prevention and treatment of cardiovascular and cerebrovascular diseases.Over the past years,lost of studies related to statins in preventing and treat ischemic cerebrovascular disease have been carried out.For clinical practice,this paper reviewed the clinical evidences of statins on primary prevention and secondary prevention for ischemic stroke as well as the safety of statins.

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Clinical application of cholesterol absorption inhibitor SUN Ying-xian 2009, 29(1): 14.  Abstract ( )   PDF (303KB) ( )   The new cholesterol absorption inhibitor Ezetimibe (EZ) could markedly reduce the LDLC level and increase the HDLC level with little adverse effect.EZ combined with statins shows cooperative effect and avoids the latent adverse effect of large dose of statins.Thus this combined therapy is a reasonable choice for the patients whose cholesterol level could not reach the standard after using optimum dose of statins.

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Clinical assessment of policosanol-a new vegetal drug for regulating serum lipid HU Da-yi,DING Rong-jing 2009, 29(1): 17.  Abstract ( )   PDF (299KB) ( )   Policosanol is a new drug for regulating lipid,which can inhibit cholesterin synthesis and increase blood clearance of lowdensity lipoprotein (LDL).It has similar effect as statins and its clinical efficiency,safety and tolerance for special people such as the old and those with hepatopath have been confirmed by many clinical studies.Policosanol combined with statins or fibrates is also safe,which can be used as primary prevention for the patients with hypercholesterinemia,high lowdensity lipoproteincholesterolor low highdensity lipoproteincholesterol and as secondary prevention for the patients who could not tolerate other lipidregulating drugs.The longterm clinical effect of Policosanol on the risk factors of atherosclerosis need further researches.