Abstract:

The new cholesterol absorption inhibitor Ezetimibe (EZ) could markedly reduce the LDLC level and increase the HDLC level with little adverse effect.EZ combined with statins shows cooperative effect and avoids the latent adverse effect of large dose of statins.Thus this combined therapy is a reasonable choice for the patients whose cholesterol level could not reach the standard after using optimum dose of statins.

Key words: antilipemic agents, hypercholesterolemia；cholesterol absorption inhibitor；Ezetimibe

摘要：

新型胆固醇吸收抑制剂依哲麦布(ezetimibe，EZ)可显著降低患者的低密度脂蛋白胆固醇(LDL-C)，升高高密度脂蛋白胆固醇(HDL-C)水平，不良反应较少。EZ与他汀类药物联合应用，有良好的药物协同效应，可避免大剂量他汀潜在的不良反应。如果患者在单用最佳剂量他汀类治疗的情况下没有达标，那么EZ联合他汀类可以是一种合理的治疗。

关键词: 降血脂药, 高胆固醇血症, 胆固醇吸收抑制剂, 依哲麦布