Abstract: The regeneration of the dental pulp-dentin complex is the core direction in the field of tooth and pulp regeneration，aiming to restore the functional deficiencies such as sensation，defense，and nutrition that result from pulp damage or inflammation. Although root canal therapy can retain affected teeth，it leads to permanent loss of the biological functions of dental pulp，increasing the risk of tooth fracture and reinfection. This review systematically discusses the core regulatory mechanisms，cutting-edge technical strategies and clinical translation bottlenecks in the field of pulp-dentin regeneration，focusing on key breakthroughs such as multi-pathway synergistic networks，dynamic microenvironment regulation and intelligent material iteration. It deeply analyzes research limitations and controversies，while envisioning future directions and optimization strategies to inform both basic research and clinical practice. 

Key words: dental pulp regeneration, dentin regeneration, dental pulp stem cells, signaling pathways, inflammation regulation, clinical translation

摘要： 牙髓-牙本质复合体再生是牙体牙髓再生领域的核心方向，旨在修复因牙髓损伤或炎症导致的感觉、防御、营养等功能受损。传统根管治疗虽可保留患牙，但会导致牙髓生物学功能的永久丧失，增加牙体折裂与再感染风险。文章系统论述牙髓与牙本质再生领域的核心调控机制、前沿技术策略及临床转化瓶颈，聚焦多通路协同网络、微环境动态调控、智能材料迭代等关键突破，深入分析研究局限与争议，展望未来研究方向和优化策略，以期为该领域基础研究与临床应用提供参考。

关键词: 牙髓再生, 牙本质再生, 牙髓干细胞, 信号通路, 炎症调控, 临床转化