Research progress of SIRT1 in suppressing inflammatory response.

Abstract

Abstract:

Abstract：SIRT1，a histone deacetylase which belongs to the sirtuin family，is expressed in most human cells. SIRT1 plays a vital role in glucolipid metabolism and aging. There are emerging results indicating that SIRT1 can inhibit the inflammatory responses via suppressing several signaling pathways. In this review we outline recent research advances on the biological characteristics of SIRT1，its anti-inflammatory effects and its inhibition to downstream signaling pathway.

Key words: SIRT1；inflammatory response；NF-&kappa, B；p38 MAPK

摘要：

SIRT1是在人类细胞中广泛存在的一种Sirtuin家族的组蛋白去乙酰化酶，参与了糖脂代谢、衰老等众多生理功能的调节。近年来的研究发现，在炎症反应中，SIRT1能够通过抑制多条细胞信号通路发挥抗炎作用。本文就SIRT1的生物学特性、抗炎作用及SIRT1对下游炎症信号通路的抑制作用等做一综述。

关键词: SIRT1；炎症反应；核因子-&kappa, B；p38丝裂原活化蛋白激酶

CLC Number:

Ｒ78

QU Liu，QIU Li-hong. Research progress of SIRT1 in suppressing inflammatory response.[J]. Acta Metallurgica Sinica.

曲柳综述，仇丽鸿审校. SIRT1抑制炎症反应的研究进展[J]. 中国实用口腔科杂志.

References

［1］ Ivy JM， Klar AJ， Hicks JB. Cloning and characterization of four SIR genes of Saccharomyces cerevisiae ［J］.Mol Cell Biol，1986， 6（2）：688-702.

［2］ Langley E， Pearson M， Faretta M，et al. Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence［J］. EMBO J，2002，21（10）：2383-2396.

［3］ Michishita E， Park JY， Burneskis JM，et al. Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins［J］. Mol Biol Cell，2005，16（10）：4623-4635.

［4］ Tanno M， Sakamoto J， Miura T，et al. Nucleocytoplasmic shuttling of the NAD+-dependent histone deacetylase SIRT1 ［J］. J Biol Chem，2007，282（9）：6823-6832 .

［5］ Hisahara S， Chiba S， Matsumoto H， et al. Histone deacetylase SIRT1 modulates neuronal differentiation by its nuclear translocation［J］. Proc Natl Acad Sci，2008 ，105（40）：15599-15604.

［9］ Lu SP， Lin SJ. Regulation of yeast sirtuins by NAD （+） metabolism and calorie restriction ［J］. Biochim Biophys Acta，2010， 1804（8）：1567-1875.

［10］ Thakur BK， Chandra A， Dittrich T， et al. Inhibition of SIRT1 by HIV-1 viral protein Tat results in activation of p53 pathway［J］. Biochem Biophys Res Commun，2012，424（2）：245-250.

［11］ Zhao W， Kruse JP， Tang Y，et al. Negative regulation of the deacetylase SIRT1 by DBC1［J］. Nature，2008， 451（7178）：587-590.

［12］ Kuno A， Hori YS， Hosoda R， et al. Resveratrol improves cardiomyopathy in dystrophin-deficient mice through SIRT1 protein-mediated modulation of p300 protein ［J］. J Biol Chem，2013， 288（8）：5963-5972.

［13］李任，仇丽鸿. 牙髓卟啉单胞菌内毒素致病性研究进展［J］.中国实用口腔科杂志，2009，2（12）：756-758.

［14］吕游，贾舸，仇丽鸿，等. 牙髓卟啉单胞菌脂多糖对成骨细胞p38丝裂原活化蛋白激酶和细胞外信号调节激酶1、2表达的影响［J］. 上海口腔医学，2012，21（4）：389-392.

［15］ Shen Z， Ajmo JM， Rogers CQ， et al. Role of SIRT1 in regulation of LPS- or two ethanol metabolites-induced TNF-α production in cultured macrophage cell lines［J］. Am J Physiol Gastrointest Liver Physiol，2009，296（5）：G1047-1053.

［16］ Lee SI， Min KS， Bae WJ， et al. Role of SIRT1 in heat stress- and lipopolysaccharide-induced immune and defense gene expression in human dental pulp cell ［J］. J Endod，2011， 37（11）：1525-1530.

［17］ Huang W， Shang WL， Wang HD， et al. SIRT1 overexpression protects murine osteoblasts against TNF-α-induced injury in vitro by suppressing the NF-κB signaling pathway［J］. Acta Pharmacol Sin， 2012， 33（5）：668-674.

［18］ Lee JH， Song MY， Song EK， et al. Overexpression of SIRT1 protects pancreatic-cells against cytokine toxicity by suppressing the nuclear factor-κB signaling pathway ［J］. Diabetes，2009， 58（2）：344-351.

［19］ Lei M， Wang JG， Xiao DM， et al. Resveratrol inhibits interleukin 1β-mediated inducible nitric oxide synthase expression in articular chondrocytes by activating SIRT1 and thereby suppressing nuclear factor-κB activity［J］. Eur J Pharmacol，2012 ，674（2-3）：73-79.

［20］ Jung YJ，Lee JE，Lee AS，et al. SIRT1 overexpression decreases cisplatin-induced acetylation of NF-κB p65 subunit and cytotoxicity in renal proximal tubule cells［J］. Biochem Biophys Res Commun，2012，419（2）：206-210.

［21］ Lan W， Petznick A， Heryati S， et al. Nuclear factor-κB： central regulator in ocular surface inflammation and disease［J］.Ocul Surf，2012，10（3）：137-148.

［22］ Zheng C， Yin Q， Wu H. Structural studies of NF-κB signaling［J］. Cell Res，2011，21（1）：183-195.

［23］楼希文，孙绍刚，王琛. 转录因子NF-κB的核内活性调控［J］.细胞生物学杂志，2009，31（6）：741-748.

［24］ Ghizzoni M， Haisma HJ， Maarsingh H， et al. Histone acetyltransferases are crucial regulators in NF-κB mediated inflammation ［J］. Drug Discov Today，2011， 16（11-12）：504-511.

［25］ Yeung F， Hoberg JE， Ramesy CS， et al. Modulation of NF-κB-dependent transcription and cell survival by the SIRT1 deacetylase［J］. EMBO J，2004，23（12）：2369-2380.

［26］ Bi XL， Yang JY， Dong YX， et al. Resveratrol inhibits nitric oxide and TNF-alpha production by lipopolysaccharide-activated microglia ［J］. Int Immunopharmacol， 2005， 5 （1）： 185-193.

［27］ Nonn L， Duong D， Peehl DM. Chemopreventive anti-inflammatory activities of curcumin and other phytochemicals mediated by MAP kinase phosphatase-5 in prostate cells［J］. Carcinogenesis，2007， 28（6）： 1188-1196.

［28］赵克森. 白藜芦醇的生物学特性和效应［J］. 中国病理生理杂志，2012，28（9）：1709-1711，1717.

［29］ Howitz KT， Bitterman KJ， Cohen HY， et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan ［J］.Nature， 2003， 425（6954）：191-196.

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