关键词: 力学信号, 牙周再生, 机械转导, 牙周-正畸联合治疗

Abstract: The goal of periodontal regeneration is to reconstruct a functional periodontal ligament-cementum-alveolar bone complex. Previous studies have primarily focused on anti-infection and inflammation control，yet recent evidence indicates that the mechanical microenvironment（e.g.，orthodontic forces，occlusal load，extracellular matrix stiffness，and viscoelasticity）serves as a critical background variable determining cellular fate. Moreover，it can substantially influence regenerative outcomes by modulating the immune microenvironment and bone remodeling processes. At the molecular level，mechanically sensitive ion channels，integrin-focal adhesion kinase complexes，and nuclear mechanosensitive structures collectively form a mechano-transduction network that converts mechanical stimuli into Ca2+ influx，RhoA/ROCK pathway activation，and transcriptional programs such as YAP/TAZ and β-catenin，thereby precisely regulating periodontal tissue repair and regeneration. At the translational level，biomaterials with programmable mechanical parameters（e.g.，stress relaxation，topological structure）have demonstrated potential of regulation beyond spatial maintenance. Clinical studies confirm the feasibility of  combined periodontal-orthodontic therapy under well-controlled inflammation，where timely and controllable orthodontic mechanical stimuli can be integrated into regenerative strategies. This article elaborates on the molecular mechanisms，experimental evidence，and clinical translation potential of mechanical signal regulation in periodontal regeneration，aiming to provide new perspectives for clinical decision-making and future research direction in combined periodontal-orthodontic therapy.

Key words: mechanical signals, periodontal regeneration, mechanotransduction, combined periodontal-orthodontic therapy