中国实用口腔科杂志

中国实用口腔科杂志 ›› 2025, Vol. 18 ›› Issue (5): 564-569.DOI: 10.19538/j.kq.2025.05.010

• 论著 • 上一篇    下一篇

浓缩生长因子辅助引导骨再生术治疗牙槽骨垂直缺损的临床效果研究

晏志强，刘    珂，黄玉莹   

  1. 北京市延庆区医院（北京大学第三医院延庆医院）口腔科，北京 102100
  • 出版日期:2025-09-30 发布日期:2025-09-30
  • 通讯作者: 晏志强

  • Online:2025-09-30 Published:2025-09-30

摘要： 目的    评估浓缩生长因子（concentrated growth factors，CGF）辅助引导骨再生术（guided bone regeneration，GBR）在单颗牙牙槽骨垂直缺损治疗中的临床效果。方法    选取2023年1月至2024年12月于北京市延庆区医院口腔科就诊的单颗牙槽骨垂直缺损患者60例，采用随机数字表法将患者分为对照组和CGF组（每组各30例）；对照组采用常规GBR治疗，CGF组采用CGF辅助GBR治疗。比较2组患者术前（基线）和术后6个月垂直骨缺损最深位点的探诊深度（probing depth，PD）、出血指数（bleeding index，BI）及牙槽骨缺损高度，术后12、24、48、72、96 h的咀嚼功能受限、肿胀及疼痛程度，以及术后2周和6个月的不良反应差异。结果    基线时，2组患者在PD、BI和牙槽骨缺损高度方面比较，差异均无统计学意义（均P > 0.05）。术后6个月，2组患者的PD和牙槽骨缺损高度均较各自基线水平显著降低，且CGF组降低更明显，差异均有统计学意义（均P < 0.05）。CGF组患者在术后48、72 h的咀嚼功能受限程度，术后48、72、96 h的肿胀程度，以及术后12、24 h的疼痛程度均显著低于对照组，差异均有统计学意义（均P < 0.05）。2组患者在术后随访期间均无不良反应发生。结论   CGF辅助GBR在牙槽骨垂直缺损治疗中显著优于常规GBR，不仅能有效促进骨再生，改善PD和骨缺损高度等临床指标，还能显著减轻患者术后不适反应，提高术后生活质量。CGF作为一种安全、有效的生物材料，值得在牙槽骨缺损治疗中推广应用。

关键词: 牙槽骨质丢失, 浓缩生长因子, 引导骨再生, 牙周再生

Abstract: Objective    To evaluate the clinical efficacy of concentrated growth factors（CGF）-assisted guided bone regeneration（GBR）in the treatment of vertical alveolar bone defects of single teeth. Methods    Totally sixty patients with vertical alveolar bone defects of a single tooth treated at the Department of Stomatology，Beijing Yanqing District Hospital from January 2023 to December 2024 were selected. Using a random number table method，patients were allocated in a 1∶1 ratio to a control group（n = 30）and a CGF group（n = 30）. The control group received conventional GBR，while the CGF group received CGF-assisted GBR. Probing depth（PD）of the deepest site of vertical bone defect，bleeding index（BI），and alveolar bone defect height were compared between the two groups at baseline and 6 months postoperatively. Mastication limitation and swelling and pain degree at 12 h，24 h，48 h，72 h and 96 h，and the differences in adverse reactions at 2 weeks and 6 months after operation were also compared. Results    There were no statistically significant differences in baseline data（PD，BI and alveolar bone defect height）between the two groups（all P > 0.05）. At 6 months postoperatively，PD and alveolar bone defect height in both groups were significantly reduced from baseline，with a more pronounced reduction in the CGF group（both P < 0.05）. The CGF group exhibited significantly lower degree of mastication limitation at 48 h and 72 h，degree swelling degree at 48 h，72 h and 96 h，and lower pain degree at 12 h and 24 h，as compared to the control group（all P < 0.05）. No adverse reactions occurred in either group during the follow-up period.  Conclusion    CGF-assisted GBR is significantly superior to conventional GBR in the treatment of vertical alveolar bone defects. It not only effectively promotes bone regeneration and improves clinical parameters such as PD and bone defect height，but also significantly reduces patients' postoperative discomfort，thereby improving their postoperative quality of life. As a safe and effective biomaterial，CGF is worthy of promotion and application in the treatment of alveolar bone defects.

Key words: alveolar bone loss, concentrated growth factors, guided bone regeneration, periodontal regeneration