关键词: D-氨基酸, 生物膜, 变异链球菌, 粪肠球菌, 牙龈卟啉单胞菌

Abstract: Biofilms are ubiquitous in nature and are related to many chronic infectious diseases. Dental plaque biofilm is a complex multi-species structure composed of aerobic and anaerobic micro-organisms，and is the initiator of dental caries，refractory chronic periapical periodontitis，periodontal disease and peri-implantitis. Bacteria in biofilms have unique gene expression and metabolic activities，which make it difficult for antibiotics to exert their antibacterial effects and  make it possible to evade the host immune system. In recent years，the inhibitory effect of D-amino acids on biofilm formation and the dispersion effect on mature biofilms have been widely studied. The article reviews the research progress in the role of D-amino acids in oral bacterial biofilms，in order to provide new ideas for the development of new therapeutic drugs for dental plaque biofilms.

Key words: D-amino acids, biofilm, Streptococcus mutans, Enterococcus faecalis, Porphyromonas gingivalis