关键词: 牙周炎症, B细胞, 破骨细胞, 核因子κB受体活化因子配体, 牙槽骨吸收

Abstract: Alveolar bone resorption is an important clinical manifestation of periodontitis. Persistent bone loss will ultimately lead to loosening and loss of teeth and affect the life quality of patients. Increased formation and enhanced activity of osteoclasts are the premise of alveolar bone resorption. The regulation of osteoclasts by host immune response caused by plaque microorganisms is the main factor influencing alveolar bone resorption. B cells are the main immune effector cells in periodontal inflammation and play a predominant role in inflammatory periodontal tissues. Studies have shown that different B-cell subsets have different regulatory effects on osteoclasts in periodontal inflammation. This article reviewed the regulatory effects of different B-cell subsets，including plasma cells，memory B cells，B-1 cells，and regulatory B cells，on osteoclasts and the mechanisms，which will provide favorable clues to the immunotherapy for periodontitis patients.

Key words: periodontal inflammation, B cells, osteoclasts, receptor activator for nuclear factor-κB ligand, RANKL, alveolar bone resorption