中国实用口腔科杂志 ›› 2012, Vol. 5 ›› Issue (06): 370-374.

• 综述 • 上一篇    下一篇

白色念珠菌分泌型天冬氨酸蛋白酶研究进展

  

  1. 中国医科大学口腔医学院综合急诊科,辽宁省口腔医学研究所口腔黏膜病学研究室,沈阳  110002
  • 收稿日期:2012-03-10 修回日期:2012-05-18 出版日期:2012-06-15 发布日期:2012-07-20

  • Received:2012-03-10 Revised:2012-05-18 Online:2012-06-15 Published:2012-07-20

摘要: 分泌型天冬氨酸蛋白酶(secreted aspartyl proteinase,SAP)是白色念珠菌的毒力因素之一,它参与白色念珠菌的黏附与侵袭,在白色念珠菌致病过程中发挥了重要作用。目前对于SAP的研究主要集中在其结构、理化性质、基因调控、抑制因素等方面,也有涉及其与相关口腔黏膜病的关系。本文就近年来有关SAP的研究进展做一综述。

关键词: 白色念珠菌, 分泌型天冬氨酸蛋白酶

Abstract: Secreted aspartyl proteinase(SAP)is one virulence of candida albicans,which participates in conglutionation and affection of candida albicans,and plays an important role in candida albicans pathogenic process. At present, the researches about SAP are mainly concentrated on structure,physical and chemical properties,gene regulation,suppression factors and so on,and there is also the relationgship with oral mucosal diseases. In this article the research progress in SAP was reviewed.

Key words: candida albicans, secreted aspartyl proteinase(SAP)