中国实用口腔科杂志

中国实用口腔科杂志 ›› 2010, Vol. 3 ›› Issue (04): 236-237.

• 论著 • 上一篇    下一篇

重组人表皮生长因子凝胶治疗复发性口腔溃疡临床疗效研究

  

  1. 1. 辽宁省人民医院口腔科，沈阳  110015；2. 大连医科大学， 辽宁  大连  116011；3. 沈阳市和平区张严口腔诊所，沈阳 110001
  • 收稿日期:2010-02-05 修回日期:2010-03-17 出版日期:2010-04-15 发布日期:2010-05-11

  • Received:2010-02-05 Revised:2010-03-17 Online:2010-04-15 Published:2010-05-11

摘要：

目的    探讨重组人表皮生长因子（rhEGF）凝胶治疗复发性口腔溃疡的临床疗效。方法    采用随机平行对照试验方法，将2007-2009年辽宁省人民医院口腔科收治64例复发性口腔溃疡（ROU）患者随机分为试验组和对照组，试验组用rhEGF凝胶局部涂药，对照组给予2%碘甘油局部涂药，分组观察，2组均治疗至溃疡愈合或2周止。结果    试验组患者溃疡平均愈合时间为（3.52±1.29）d，对照组为（7.58±2.07）d，两组比较，差异有统计学意义（P < 0.05）。试验组总有效率（96.9%）明显高于对照组（62.5%）（P < 0.05）。结论    重组人表皮生长因子凝胶对口腔溃疡创面具有明显的促进愈合作用，应用方便、安全。

关键词: 重组人表皮生长因子, 复发性口腔溃疡, 碘甘油

Abstract:

Objective    To investigate the effect of recombinant human epidermal growth factor（rhEGF） gel in treating recurrent oral ulceration. Methods    A randomized controlled trial was adopted. Totally 64 patients were divided into two groups：test group （n=32）and control group（n=32）. The test group was given rhEGF gel and control group was given iodine glycerin until the restoration of oral ulcer or for 2 weeks. Results    The average curing time of the treatment group was 3.52±1.29 days，but that of the control group was 7.58±2.07 days.The excellent rate of the treatment group（96.9%） was significantly higher than that of the control group（62.5%）（P < 0.01）.Conclusion    RhEGF gel can promote the restoration of oral ulcer with much convenience and safety．

Key words: recombinant human epidermal growth factor（rhEGF）；recurrent oral ulceration（ROU）；iodine glycerin