中国实用口腔科杂志

中国实用口腔科杂志

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成骨细胞和破骨细胞的传导通路和相关因子

赵秀敏 综 述，艾红军，常 新 审 校   

  1. 大连医科大学附属第二医院口腔科
  • 收稿日期:2008-12-23 修回日期:2009-03-02 出版日期:2009-03-15 发布日期:2009-03-15

  • Received:2008-12-23 Revised:2009-03-02 Online:2009-03-15 Published:2009-03-15

摘要：

牙槽骨在一生中都进行着不断的更新与重建，牙槽骨重建是一个复杂的生化反应过程，该过程包括破骨细胞（osteoclast，OC）介导的骨吸收和成骨细胞（osteoblast，OB）介导的骨形成。在这个过程中有多种细胞因子参与，研究OB和OC的传导通路和相关因子具有重要的理论和实践意义。

关键词: 成骨细胞, 骨形成蛋白, 破骨细胞, 信号传导通路

Abstract:

Alveolar bone are constantly engaged in updating and reconstruction during their lives. The reconstruction of alveolar bone is a complex biochemical reaction process，which includes osteoclasts-mediated bone resorption and osteoblasts-mediated bone formation. A variety of cytokines are involved in this process，so studying the transduction pathway of OB and OC and related factors has great theoretical and practical significance.

Key words: osteoblast, BMPs, osteoclast, signaling pathway