关键词: 锌, 细胞凋亡, 口腔种植体, 成骨细胞

Abstract:

Zinc is a necessary trace element for organism，which important to the physiological regulation of organs and tissues. Zinc has an important biological effect in the process of apoptosis；it can inhibit apoptosis and induce apoptosis，both depending on intracellular concentration of zinc. The mechanism of zinc in influencing apoptosis is complex，which is the result of joint action of a variety of factors. Appropriate concentration of zinc coating on the surface of dental implants，which are made of pure titanium，modified by micro-arc oxidation，can promote the proliferation and differentiation of osteoblasts and the formation of bone matrix；also，different concentrations of zinc can affect the apoptosis of osteoblastic cells，probably through a mitochondria-mediated pathway.

Key words: zinc, apoptosis, dental implant, osteoblast