中国实用口腔科杂志

中国实用口腔科杂志

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牙龈炎与腔隙性脑梗死血流变学水平关系研究

纪 悦1，2，林晓萍1   

  1. 国医科大学盛京医院口腔内科
  • 收稿日期:2009-04-10 修回日期:2009-05-20 出版日期:2009-06-15 发布日期:2009-06-15

  • Received:2009-04-10 Revised:2009-05-20 Online:2009-06-15 Published:2009-06-15

摘要：

目的 研究牙龈炎对腔隙性脑梗死血流变学水平的影响。方法 从2008年6月至2008年12月辽宁省金秋医院体检人群选择60岁以上腔隙性脑梗死患者123例，分为重度牙龈炎组（33例，牙龈指数 ≥ 2.1）和轻度牙龈炎组（90例，牙龈指数 < 2.1）。对其全血高切黏度（ηbH）、中切黏度（ηbM）、低切黏度（ηbL）、血浆黏度（ηP）、全血还原黏度（RV）、红细胞压积（HCT）和纤维蛋白原（Fib）等指标进行测定并比较分析。结果 重度牙龈炎组全血中切黏度和纤维蛋白原均显著高于轻度牙龈炎组（P < 0.05），其它血流变学指标两组间差异无统计学意义。结论 重度牙龈炎使腔隙性脑梗死患者的部分血流变学指标发生改变，因而可能增加腔隙性脑梗死复发机会。

关键词: 牙龈炎, 血流变学, 纤维蛋白原, 腔隙性脑梗死

Abstract:

Objective To investigate the effects of gingivitis on hemorrheology of patients with lacunar infarction. Methods Totally 123 cases of elderly patients with lacunar infarction were studied，in which 33 patients with the gingival index ≥ 2.1 as the group of severe gingivitis，another 90 patients with the gingival index < 2.1 as the group of mild gingivitis. The hemorrheological parameters，whole blood viscosity （at high，middle and low shear rates），plasma viscosity，whole blood reducing viscosity，hematocrit and plasma fibrinogen of these patients were determined and comparatively analyzed. Results The whole blood viscosity at middle shear rate and plasma fibrinogen of the severe gingivitis group were significantly higher than that of the mild gingivitis group（P < 0.05）. The difference of other hemorrheologieal parameters between two groups was not significant. Conclusion Two of hemorrheologieal parameters are altered in patients with lacunar infarction by severe gingivitis，which may increase the chance of relapse of lacunar infarction.

Key words: gingivitis, hemorrheology, fibrinogen, lacunar infarction