关键词: 二膦酸盐, 颌骨骨坏死, 治疗

Abstract:

Bisphosphonates are the most commonly used drugs to treat bone metastases. In recent years， many authors found that long-term use of bisphosphonate drugs can lead to bisphosphonate-related osteonecrosis of the jaws （BRONJ）. The life quality of patients with the BRONJ symptoms （oral fistula， swelling， limited opening and fractures）will be seriously affected. These patients often seek help in dentistry，therefore the treatment knowledge of this disease is very important. This article reviews the recent literature about treatment for this disease，hoping to help oral clinical work.

Key words:  , bisphosphonate；osteonecrosis of the jaws；treatment