中国实用口腔科杂志 ›› 2025, Vol. 18 ›› Issue (5): 598-606.DOI: 10.19538/j.kq.2025.05.015

• 综述 • 上一篇    下一篇

头颈部神经鞘瘤的治疗方法研究进展

徐    勇,于汶源,邵    禹,徐    进,胡绍婷,李龙飞,陈正岗   

  1. 滨州医学院口腔医学院,山东 烟台 264003
  • 出版日期:2025-09-30 发布日期:2025-09-30
  • 通讯作者: 陈正岗
  • 基金资助:
    山东省医药卫生科技项目(202308020420)

  • Online:2025-09-30 Published:2025-09-30

摘要: 头颈部神经鞘瘤(head and neck schwannomas,HNS)是一种较为罕见的囊实性良性肿瘤,偶有恶变,常沿神经轴向两侧发展,穿刺可见血样不凝结褐色液体。HNS一般生长缓慢,常表现为压痛、放射痛或其他相关神经症状,对常规放射治疗不敏感,大多采用手术摘除的方式治疗,但常因与周围组织粘连而损伤肿瘤来源的神经,且术后复发率极高。近年来,随着治疗手段的不断进步,HNS的治疗取得了显著进展。文章主要就HNS的治疗方法(包括传统手术、微创技术、射频消融技术、立体定向放射治疗、靶向治疗等)做一综述,并探讨当前研究热点问题,展望未来研究方向。

关键词: 头颈部神经鞘瘤, 微创技术, 射频消融技术, 立体定向放射治疗, 靶向治疗

Abstract: Head and neck schwannomas are relatively uncommon benign tumors that may present with both cystic and solid components,with the potential for malignant transformation in rare instances. These tumors often develop bilaterally along the nerve axis and,upon aspiration,typically yield a brownish,blood-tinged,non-coagulated fluid. Schwannomas in the head and neck region generally exhibit slow growth and are frequently associated with symptoms such as tenderness,radiating pain,and other neurological manifestations. Head and neck schwannomas are generally resistant to conventional radiotherapy,with surgical excision being the most commonly employed treatment modality. However,surgical intervention is often complicated by adhesion to adjacent tissues,which can result in damage to the nerve of tumor origin. Additionally,the recurrence rate following surgery is extremely high. In recent years,significant advancements in therapeutic approaches have led to notable progress in the management of head and neck schwannomas. This article reviews current treatment approaches,including traditional surgical resection,minimally invasive techniques,radiofrequency ablation,stereotactic radiosurgery,and targeted therapies,discusses current research hotspots and looks forward to future  research directions.

Key words: head and neck schwannomas, minimally invasive techniques, radiofrequency ablation, stereotactic radiation therapy, targeted therapy