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02 September 2020, Volume 36 Issue 9 Previous Issue    Next Issue

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Role of ultrasound screening in the prevention and control of birth defects. CHEN Xin-lin 2020, 36(9): 800-803.  DOI: 10.19538/j.fk2020090103 Abstract ( )   The advantages and disadvantages of two-dimensional ultrasound，color Doppler，ultrasound in early pregnancy，ultrasound in middle and late pregnancy and three-dimensional ultrasound in the clinical screening of birth defects are summarized.Two-dimensional ultrasound and color Doppler are still the most important methods to screen for and diagnose birth defects.Prenatal echocardiographers receiving standardized training is the basis to ensure the goal of preventing and controlling birth defects by ultrasound screening.

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Application of high throughput sequencing in prenatal diagnosis. HANG Jin-man，ZHU Bao-sheng 2020, 36(9): 804-806.  DOI: 10.19538/j.fk2020090104 Abstract ( )   High-throughput sequencing techniques such as CNV seq，gene panel，WES and others have been used in prenatal diagnosis.Each of them has its own advantages and disadvantages.There are many guidelines about CNV interpretation and WES application.Based on practical experience，we discuss how to apply several techniques reasonably in prenatal diagnosis.It is expected that WGS can also be used in prenatal diagnosis in the future.

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Maternal-Infant outcomes and intervention strategies of common intrauterine infections. YIN Yi-fei，ZHU Bao-sheng 2020, 36(9): 806-811.  DOI: 10.19538/j.fk2020090105 Abstract ( )   Pathogenic microorganisms can gain access to the uterine cavity by ascending from the lower reproductive tract or via placenta transmission，and may result in many adverse maternal and infant outcomes，including miscarriage，stillbirth，premature delivery，congenital defects and long-term sequelae.The more common causes of infection include sexually transmitted infections，classic "TORCH" infections and some emerging infectious diseases.This article refers to the latest international researches and guidelines to explain the mechanism of intrauterine infection，maternal-infant outcomes and intervention measures，so as to optimize the pregnancy management of intrauterine infections.

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The prenatal genetic counseling of advanced maternal age. JIANG Yu-lin，LIU Jun-tao 2020, 36(9): 811-814.  DOI: 10.19538/j.fk2020090106 Abstract ( )   Advanced maternal age refers to the situation where the age of a pregnant woman is 35 years or older.It has become a hot issue of concern in China's perinatal medicine in recent years due to its increasing incidence.The importance of prenatal screening and diagnosis has been emphasized，as well as the risk issue of advanced paternal age，which often accompanies advanced maternal age.Appropriate counseling and clinical management of these issues is an important aspect of accomplishing high quality perinatal care for advanced maternal age-related pregnancies.

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Prenatal screening，diagnosis and intrauterine therapy for twin pregnancy：referral is the key. ZOU Gang，SUN Lu-ming 2020, 36(9): 814-817.  DOI: 10.19538/j.fk2020090107 Abstract ( )   The prenatal screening and diagnosis of twin pregnancy is highly professional and complex.The measurement of nuchal translucency combined with cfDNA testing of maternal blood can promote the detection rate of aneuploidy and reduce unnecessary invasive prenatal diagnosis procedure.Precise intrauterine intervention is based on accurate prenatal diagnosis and the special management of twins should be referred to a professional prenatal diagnosis center or a regional fetal medical center.