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02 March 2016, Volume 32 Issue 2 Previous Issue    Next Issue

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Counseling of preimplantation genetic diagnosis and screening. QU Wen-yu. 2016, 32(2): 231-234.  DOI: 10.7504/fk2016020106 Abstract ( )   Abstract:With the rapid development of molecular biology and its application in the field of reproduction, genetic counseling before PGD /PGS has become more and more complex. In this process，couples should be provided with evidence-based information on the techniques and their implications,as well as the Pros and cons of PGD. Of course, possible outcomes ,technical defects and security issues of PGD and PGS should also be informed. Meanwhile, the successful pregnant women after PGD / PGS should still do routine prenatal diagnosis, which is essential to the security of PGD/PGS.

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Optimal time and method to perform embryo biopsy and its influence on the outcome of preimplantation genetic diagnosis and screening. HUANG Jin, LIU Ping. 2016, 32(2): 234-237.  DOI: 10.7504/fk2016020107 Abstract ( )   Abstract：Cells can be obtained through embryo biopsy or preimplantation genetic diagnosis or preimplantation genetic screening, including polar body biopsy, blastomere biopsy and trophectoderm cells biopsy. Embryo biopsy should not only ensure that the obtained cells can be applied to genetic testing, but also reduce the impact of biopsy on the development of embryos as much as possible. Therefore, it is very important to select an optimal time and method to perform the embryo biopsy.

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Selection of ovarian stimulation protocols and characteristics analysis of preimplantation genetic diagnosis cycles. HU Xiao-kun，XU Yan-wen. 2016, 32(2): 237-240.  DOI: 10.7504/fk2016020108 Abstract ( )   Abstract:Controlled ovarian hyperstimulation（COH）plays a key role in preimplantation genetic diagnosis （PGD）.The ratio of genetically available transferable embryos after PGD to biopsied embryos is different among various hereditary diseases undergoing PGD，thus，the demand for the number of oocytes is different.Hereditary diseases may have impact on ovarian response to some extent.We firstly introduce the ratio of genetically available transferable embryos to biopsied embryos determined by hereditary pattern of various hereditary diseases，then emphasize the characteristics of COH，including the impact of hereditary diseases in PGD cycles on the ovarian response to COH，the choice of COH protocols in clinical work and the cutoff value of the number of oocytes reported from the recent literatures.

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Preimplantation genetic screening:controversies and reintroduction. HUA Rui，QUAN Song. 2016, 32(2): 240-245.  DOI: 10.7504/fk2016020109 Abstract ( )   Abstract：It has been almost a decade since the first preimplantation genetic screening （PGS） cycle was conducted. However, the use of PGS was controversial with regard to its indication，safety，clinical efficiency，ethical management, etc.With the advancement of single cell molecular genetic technologies and the improvement of resolution and accuracy，it is necessary that PGS should be reintroduced and revalued.

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Application of single nucleotide polymorphism microarray in preimplantation genetic diagnosis of chromosomal translocation carrier. LI Gang. 2016, 32(2): 245-247.  DOI: 10.7504/fk2016020110 Abstract ( )   Abstract: As one of the common reasons of infertility，chromosomal translocation is the popular indication of preimplantation genetic diagnosis （PGD）.Recently，single nucleotide polymorphism microarray has been applied to the PGD as a new technology.Compared with the traditional methods，the SNP microarray has more advantages.In this article，authors will review the principle of SNP microarray，the present situation of application of SNP-PGD,indication，advantages and disadvantages.The perspective of SNP-PGD will be discussed as well.

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Application of next-generation sequencing in preimplantation genetic diagnosis. XIE Ping-yuan,HU Liang,LIN Ge. 2016, 32(2): 247-251.  DOI: 10.7504/fk2016020111 Abstract ( )   Abstract:The next-generation sequencing technology applied to preimplantation genetic diagnosis and screening is developing rapidly,which not only can perform extensive comprehensive chromosome screening/diagnosis,but also can analyze the single-gene disorders.This article reviews the application of the next-generation sequencing technology in the preimplantation genetic diagnosis of chromosomal disorders and single-gene disorders, and preimplantation genetic screening.

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Difficulties in performing preimplantation genetic diagnosis of single gene disorders and analysis of misdiagnosis causes. XU Yan-wen. 2016, 32(2): 251-254.  DOI: 10.7504/fk2016020112 Abstract ( )

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Ethical issues in preimplantation genetic diagnosis and screening. LU Xiao-wei，FENG Yun. 2016, 32(2): 255-259.  DOI: 10.7504/fk2016020113 Abstract ( )