Acta Metallurgica Sinica

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Antenatal neuroprotection for preterm infants.

QIU Li-liHU Ya-li.   

  1. Department of Obstetrics and Gynecology,Nanjing Drum Tower Hospital,The Affiliated Hospital of Nanjing University Medical Schod,Nanjing 210008,China
  • Online:2014-06-02 Published:2014-05-22

早产的脑神经保护

仇黎丽胡娅莉   

  1. 作者单位:南京大学医学院附属鼓楼医院妇产科,江苏 南京210008
  • 通讯作者: 胡娅莉 

Abstract:

Abstract:Each year,more than 15 million babies are born preterm worldwide,which becomes the largest cause of neonatal deaths.In addition to its significant contribution to mortality,some effects of preterm birth on survivors are life-long impairing such as cerebral palsy,mental retardation,and so on.It is critical to prevent against neurological deficit in utero.Several randomized controlled trials and Cochrane reviews demonstrated that giving magnesium sulfate antenatally to women at risk of preterm birth could reduce the risk of the newborn cerebral palsy.However it remains elucidate detailed indications for different pretermbirth,magnesium sulfate dosage,treatment window and course.

Key words: preterm birth, cerebral palsy, magnesium sulfate, neuroprotection

摘要:

全球每年约有1500万早产儿出生,早产已成为新生儿死亡的首要原因,存活早产儿也面临脑性瘫痪、认知障碍及运动异常等严重脑损伤并发症。这些远期不良预后缺乏有效治疗措施,所以宫内早期预防早产脑损伤变得尤为重要。一些随机对照试验和荟萃分析显示,产前应用硫酸镁能减少早产儿脑瘫发生率。然而,不同早产病因、硫酸镁合适治疗窗、硫酸镁给药剂量等仍须进一步阐明。

关键词: 早产, 脑性瘫痪, 硫酸镁, 脑神经保护

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