中国实用妇科与产科杂志 ›› 2022, Vol. 38 ›› Issue (6): 609-613.DOI: 10.19538/j.fk2022060109

• 专题笔谈 • 上一篇    下一篇

生育力重建的现状和未来

  

  1. 中山大学附属第一医院生殖医学中心,广东 广州 510080
  • 出版日期:2022-06-02 发布日期:2022-06-02
  • 通讯作者: 周灿权
  • 基金资助:
    广东省生殖医学重点实验室(2020B1212060029)

Fertility restoration: present and future. 

  1. Reproductive Medicine Center,The First Affiliated Hospital of Sun Yat-sen University,Guangzhou 510080,China
  • Online:2022-06-02 Published:2022-06-02

摘要: 近20年来,中国的出生率和育龄夫妇的总和生育率持续处于低位。随着全面二孩政策的实施,出生人口数于2016年达到高点后,近5年逐年明显下降。探索生育力重建的治疗措施对中国经济社会的可持续发展具有重大意义。女性在人类生殖繁衍活动中具有不可或缺的重要地位,诸多因素可导致女性生殖相关组织、器官的功能减退甚至损毁,随之生育力丧失。探索生育力重建技术既是目前亟需解决的临床技术问题,也将加深我们对人类生殖细胞发育调控及不孕不育发病机制的理解,是维护生殖健康的关键。文章从生育力重建的角度,对女性生育力重建技术的现状、研究进展以及未来可能的发展方向加以阐述。

关键词: 生殖健康, 生育力重建, 人造子宫, 干细胞分化, 人造生命

Abstract: The birth rate in China and the total fertility rate of China's couples of reproductive age have been consistently low for nearly two decades.After the full implementation of the two-child policy,the number of births reached a high point in 2016 and has been declining significantly year by year for the past five years.Exploring treatment measures for fertility restoration is of great significance for the sustainable development of our economy and society.Females play an indispensable role in human reproduction and reproductive activities,and many factors lead to the reduction or even destruction of tissues,organs,and functions related to female reproduction,followed by the loss of fertility.Exploring fertility restoration technology is not only an urgent clinical technical problem but also deepens our understanding of the regulation of human germ cell development and the pathogenesis of infertility,which are key to maintaining reproductive health.In this article,we will review the current status,research progress,and possible future directions of female fertility restoration techniques from a restoration perspective.

Key words: reproductive health, fertility restoration, artificial womb, stem cell differentiation, artificial life

中图分类号: