中国实用妇科与产科杂志
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摘要：
子痫前期是严重威胁母胎安全的常见产科疾病，降低其发病率具有重要意义。近年研究表明，阿司匹林作用于血小板环氧化酶1（cyclooxygenase1，COX1）等多个子痫前期发病的关键靶点，从而在预防疾病发生中发挥重要作用。掌握阿司匹林预防子痫前期的应用指征及时机，排除应用禁忌证后合理用药，可有效降低子痫前期的发病率，或减缓其病情严重程度。
关键词: 子痫前期, 阿司匹林, 环氧化酶1, 可溶性血管内皮生长因子受体1
Abstract:
Preeclampsia is a common obstetric disease that seriously threatens maternal and fetal safety，so reducing its incidence is of great significance.Recent studies have shown that aspirin plays an important role in the prevention of preeclampsia by acting on the key targets of preeclampsia，such as cyclooxygenase 1 （COX1）.To grasp the indications and timing of aspirin to prevent preeclampsia along with reasonable medication after excluding the contraindications can effectively reduce the incidence of preeclampsia，or slow down the severity of the disease.
Key words: preeclampsia, aspirin, cyclooxygenase 1, soluble vascular endothelial growth factor receptor 1
中图分类号:
R714.24+4
陈国庆，牛建民. 阿司匹林预防子痫前期的相关问题[J]. 中国实用妇科与产科杂志, DOI: 10.19538/j.fk2017070107.
CHEN Guo-qing， NIU Jian-min. Related problems of aspirin in preventing preeclampsia[J]. Acta Metallurgica Sinica, DOI: 10.19538/j.fk2017070107.
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https://www.zgsyz.com/zgsyfck/CN/Y2017/V33/I7/688
