辅助生殖周期中超促排卵对子宫内膜容受性的影响

doi:10.7504/fk2014120107

摘要/Abstract

摘要：

随着辅助生殖技术水平不断提高，子宫内膜容受性成为制约临床妊娠率提高的关键因素。促排卵应用的大量性激素类药物，以及因为多个卵泡发育引起的体内一系列远超正常生理的激素水平和蛋白因子的改变，都有可能会对子宫内膜容受性造成一定的影响。鉴于国内外现有的研究主要从子宫内膜超声形态学、组织学、分子生物学及基因组学对子宫内膜容受能力进行评估，该文也将从这几个方面论述超促排卵对子宫内膜容受性的影响。

关键词: 辅助生殖技术, 子宫内膜容受性, 控制性超排卵

Abstract:

Abstract: Despite many advances in assisted reproduction techniques, implantation rates are still low after in vitro fertilization (IVF) and controlled ovarian stimulation. Successful implantation and pregnancy require a vital embryo and an effective molecular dialogue with a ‘receptive’ endometrium. Endometrial receptivity is the rate-limiting step for the success of IVF. Ovarian stimulation is used in IVF programs to collect multiple oocytes and to produce multiple embryos per cycle of treatment. Although this procedure enables selection of high quality embryos for transfer, ovarian stimulation also results in supraphysiological levels of P and E2. These elevated sex steroid concentrations may impair endometrial receptivity. We try to evaluate the influence of COH on endometrial receptivity from ultrasonic imaging, morphocytology, histomorphology, molecular biology, and gene microarray analysis.

Key words: assisted reproductive technology, endometrial receptivity, controlled ovarian hyperstimutation

中图分类号:

R321-33

金丽，潘洁雪，丁国莲，黄荷凤. 辅助生殖周期中超促排卵对子宫内膜容受性的影响[J]. 中国实用妇科与产科杂志, DOI: 10.7504/fk2014120107.

JIN Li, PAN Jie-xue, DING Guo-lian, HUANG He-feng.. The effect of controlled ovarian stimulation on endometrial receptiveity during the assisted reproductive process.[J]. Acta Metallurgica Sinica, DOI: 10.7504/fk2014120107.

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