关键词: 扳机, 人绒毛膜促性腺激素, 卵胞浆内单精子注射, 结局

Abstract:

Abstract： Objective To discuss the effect of different HCG doses according to serum E2 level on HCG day for triggering final oocyte maturation on ICSI outcomes. Methods This was a prospective study including 117 couples with an indication for ICSI between Jan. 2012 and Dec. 2012 at Reproductive Center of Ruijin Hospital. The dose of HCG for final oocyte maturation was used according to serum E2 level on HCG day as follows: if serum E2 concentration was ≤16 515 pmol/L, the dose of HCG was 7000 IU, serum E2 concentration ranged from 16 516 pmol/L to 23 854 pmol/L, the dose of HCG was 5000 IU, serum E2 concentration was ≥23 855 pmol/L, the dose of HCG was 3000 IU. The outcomes of three groups were compared. Results There were no significant differences among three groups on MⅡ rate and fertilization rate. The cleavage rate of 7000 IU group was significantly lower than 5000 IU group (96.43% vs. 99.62%). But the viability embryo rate of 7000 IU group was significantly higher than both 3000 IU group and 5000 IU group (65.43 vs. 55.69% and 57.74%, respectively). There was one moderate OHSS patient in 5000 IU group. There were no significant differences among three groups on mean number of embryo transfer, clinical pregnancy rate and implantation rate in fresh embryo-transfer cycles. Conclusion Using different doses of HCG according to serum E2 level on HCG day to trigger final oocyte maturation does not affect oocyte maturation and pregnancy rate. The principle that patient with high E2 concentration was given lower HCG dose and patient with low E2 concentration was given higher HCG dose was available.

Key words: trigger, HCG, ICSI；outcomes