多囊卵巢综合征流行病学研究

摘要/Abstract

摘要：

多囊卵巢综合征(polycystic ovary syndrome, PCOS)是育龄妇女最常见的内分泌紊乱性疾病之一，我国育龄妇女患病率5.6%，也是引起无排卵性不孕的主要原因。PCOS以月经紊乱、多毛、不孕、高雄激素症等为主要表现，易发生胰岛素抵抗、高胰岛素血症、2型糖尿病(diabetes mellitus, T2DM)（非胰岛素依赖型）、高血脂、心血管疾病、代谢综合征、睡眠窒息、非酒精性脂肪肝、妊娠期糖尿病和妊娠期高血压疾病等，PCOS患病率与不同种族、地区、调查对象和诊断标准有关，大多数文献报道其患病率在5%～10%。

关键词: 多囊卵巢综合征, 流行病学

Abstract:

Abstract:Polycystic ovary syndrome (PCOS) is a common metabolic dysfunction and heterogeneous endocrine disorder in women of reproductive age.PCOS is characterized by a clustering of hyperandrogenism, hyperinsulinemia, hypersecretion of LH, menstrual dysfunction, hirsutism, infertility and pregnancy and neonatal complications. PCOS also contributes to other long-term health risks, metabolic complications and psychological problems, such as type II diabetes mellitus (DM2), cardiovascular disease (CVD), poor self-esteem, venous thromboembolism (VTE) and anxiety. In addition, a wide range in the incidence of PCOS has been reported in small samples from different countries. As a result, most studies quoted a prevalence of PCOS ranging from 5% to 10%. However, previous reports from a variety of different countries demonstrate the diversity in the incidence of PCOS, and the prevalence of PCOS also depends on the criteria used to evaluate this syndrome. Different PCOS prevalence surveys have been carried out in specific populations using special diagnostic criteria.

Key words: polycystic ovary syndrome, epidemiology

中图分类号:

R711.75

乔杰，李蓉，李莉，等. 多囊卵巢综合征流行病学研究[J]. 中国实用妇科与产科杂志.

参考文献



[1］ Stein IF，Leventhal NL. Amenorrhea associated with bilateral polycystic ovaries[J]. Am J Obstet Gynecol,1935,29: 181-191.

[2］ Azziz R, Woods KS, Reyna R,et al. The prevalence and features of the polycystic ovary syndrome in an unselected population[J]. J Clin Endocrinol Metab,2004,89: 2745-2749.

[3］ Knochenhauer ES, Key TJ, Kahsar-Miller M,et al. Prevalence of the polycystic ovary syndrome in unselected black and white women of the southeastern United States: a prospective study[J]. J Clin Endocrinol Metab,1998,83: 3078-3082.

[4］ Diamanti-Kandarakis E, Kouli CR, Bergiele AT,et al. A survey of the polycystic ovary syndrome in the Greek island of Lesbos: hormonal and metabolic profile[J]. J Clin Endocrinol Metab,1999,84: 4006-4011.

[5］ Asuncion M, Calvo RM, San Millan JL,et al. A prospective study of the prevalence of the polycystic ovary syndrome in unselected caucasian women from Spain[J]. J Clin Endocrinol Metab,2000,85: 2434-2438.

[6］ Michelmore KF, Balen AH, Dunger DB,et al. Polycystic ovaries and associated clinical and biochemical features in young women[J]. Clin Endocrinol (Oxford),1999,51: 779-786.

[7］ Goodarzi MO, Quin ones MJ, Azziz R,et al. Polycystic ovary syndrome in Mexican Americans: prevalence and association with the severity of insulin resistance[J]. Fertil Steril,2005,84: 766-769.

[8］ Rong Li, Qiufang Zhang, Dongzi Yang,et al. Prevalence of polycystic ovary syndrome in women in China: A Large Community-Based Study[J]. Hum Reprod,2013, 7: 1-8. 

[9］ Speroff L, Fritz MA. Clinical gynecologic endocrinology and infertility[M]. 7th ed. Philadelphia (PA): Lippincott Williams and Wilkins, 2005:123.

[10］ Laven JS,Imani B, Eijkemans MJ,et al. New approach to polycystic ovary syndrome and other forms of anovulatory infertility[J].Obstet Gynecol Surv,2002, 57 (11): 755-767.

[11］ Bili H, Laven J, Imani B,et al. Age-related differences in features associated with polycystic ovary syndrome in normogonadotrophic oligo-amenorrhoeic infertile women of reproductive years[J].Eur J Endocrinol,2001, 145 (6): 749 755.

[12］ The Rotterdam ESHRE/ASRM-Sponsored PCOS consensus workshop group.Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS) [J]. Hum Reprod,2004,19 (1): 41-47.

[13］ Li R, Qiao J, Yang D,et al.Epidemiology of hirsutism among women of reproductive age in the community: asimplifiedscoringsystem[J]. Eur J Obstet Gynecol Reprod Biol,2012, 163(2): 165 169.

[14］ Norman RJ, Wu R, Stankiewicz MT. Polycystic ovary syndrome[J]. Med J Aust,2004,180 (3): 132-137.

[15］ Imani B, Eijkemans MJ, de Jong FH,et al.Free androgen index and leptin are the most prominent endocrine predictors of ovarian response during clomiphene citrate induction of ovulation in normogonadotropic oligoamenorrheic infertility[J].J Clin Endocrinol Metab,2000,85 (2): 676-682.

[16］ Carmina E, Lobo RA. Use of fasting blood to assess the prevalence of insulin resistance in women with polycystic ovary syndrome[J]. Fertil Steril,2004,82: 661-665.

[17］ DeUgarte CM, Bartolucci AA, Azziz R. Prevalence of insulin resistance in the polycystic ovary syndrome using the homeostasis model assessment[J]. Fertil Steril,2005,83: 1454-1460.

[18］ Dunaif A, Segal KR, Futterweit W, et al. Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome[J].Diabetes ,1989,38 (9): 1165-1174.

[19］ American Diabetes Association.Consensus Development Conference on Insulin Resistance, 5-6 November 1997[J].Diabetes Care, 1998, 21 (2): 310-314.

[20］ Expert panel on detection, evaluation, and treatment of high blood cholesterol in adults. Executive summary of the third report of The National Cholesterol Education Program (NCEP) Expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) [J]. JAMA ,2001,285 (19): 2486-2497.

[21］ Pierpoint T, McKeigue PM, Isaacs AJ, et al. Mortality of women with polycystic ovary syndrome at long-term follow-up[J]. J Clin Epidemiol, 1998,51: 581-586.

[22］ Wild R, Painter P, Coulson P, et al. Lipoprotein lipid concentrations and cardiovascular risk in women with polycystic ovary syndrome[J]. J Clin Endocrinol Metabl,1985, 61: 946-951.

[23］ Pierpoint T, McKeigue PM, Isaacs AJ, et al. Mortality of women with polycystic ovary syndrome at long-term followup[J]. J Clin Epidemiol ,1998,51: 581-586.

[24］ Hahn S, Tan S, Elsenbruch S,et al. Clinical and biochemical characterization of women with polycystic ovary syndrome in north Rhine-Westphalia[J]. Horm Metab Res,2005,37: 438-444.

[25］ Pasquali R, Casimirri F, Venturoli S, et al. Body fat distribution has weight-independent effects on clinical, hormonal, and hirsutmetabolic features of women with polycystic ovary syndrome[J]. Metab Clin Exp,1994,43 (6): 706-713.

[26］ Fogel RB, Malhotra A, Pillar G, et al. Increased prevalence of obstructive sleep apnea syndrome in obese women with polycystic ovary syndrome[J]. J Clin Endocrinol Metab,2001,86:1175-1180.

[27］ Fauser BC, Tarlatzis BC, Rebar RW,et al. et al. Consensus on women's health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group[J]. Fertil Steril,2012,97(1):28-38.

[1]	乔杰，齐新宇，徐雅兰，庞艳莉. 关注影响女性健康的重要生殖内分泌疾病多囊卵巢综合征[J]. 中国实用妇科与产科杂志, 2020, 36(1): 1-9.
[2]	李昕. 多囊卵巢综合征心理问题及管理[J]. 中国实用妇科与产科杂志, 2019, 35(3): 295-297.
[3]	李琳，杨冬梓. 青春期多囊卵巢综合征筛查与管理[J]. 中国实用妇科与产科杂志, 2019, 35(3): 291-295.
[4]	罗卓野，张杰. 多囊卵巢综合征伴肥胖者助孕前处理[J]. 中国实用妇科与产科杂志, 2019, 35(3): 287-291.
[5]	陈丽娜，官文征. 多囊卵巢综合征糖脂代谢异常筛查及管理[J]. 中国实用妇科与产科杂志, 2019, 35(3): 283-286.
[6]	李光辉，罗金英. 多囊卵巢综合征孕期代谢特点及其管理[J]. 中国实用妇科与产科杂志, 2019, 35(3): 278-283.
[7]	朱茜，倪郝. 多囊卵巢综合征高雄激素特征及管理[J]. 中国实用妇科与产科杂志, 2019, 35(3): 274-278.
[8]	鹿群，赵璐璐. 多囊卵巢综合征主要鉴别诊断[J]. 中国实用妇科与产科杂志, 2019, 35(3): 271-274.
[9]	林佳，蒋琪. 多囊卵巢综合征诊断分型及临床意义[J]. 中国实用妇科与产科杂志, 2019, 35(3): 267-271.
[10]	钱易，马翔. 多囊卵巢综合征诊断标准解读[J]. 中国实用妇科与产科杂志, 2019, 35(3): 265-267.
[11]	袁莹莹，赵君利. 多囊卵巢综合征流行病学特点[J]. 中国实用妇科与产科杂志, 2019, 35(3): 261-264.
[12]	陈子江，崔琳琳. 重视多囊卵巢综合征孕产期管理[J]. 中国实用妇科与产科杂志, 2019, 35(3): 257-260.
[13]	杨丽，张弘. 代谢综合征与复发性流产[J]. 中国实用妇科与产科杂志, 2018, 34(9): 986-989.
[14]	夏舟岚，陆月红，马英英，陈惠娟. 自身免疫性甲状腺炎与排卵障碍相关性研究[J]. 中国实用妇科与产科杂志, 2015, 31(3): 239-241.
[15]	张丹，徐艳文，王子莲，王增艳，王琼，苗本郁，周灿权. 多囊卵巢综合征年轻不孕患者体外受精-胚胎移植结局研究[J]. 中国实用妇科与产科杂志, 2014, 30(7): 534-537.