关键词: 阴道上皮内瘤变, 人乳头瘤病毒, 宫颈上皮内瘤变

Abstract:

Objective:To investigate the clinical characteristics，risk factors，diagnosis and treatment，prognosis of vaginal intraepithelial neoplasia(VAIN). Methods:A retrospective study was made of 28 patients with VAIN，who were hospitalized at Peking Union Medical College Hospital between 2005 and 2011Those patients’ clinical characteristics，liquidbased cytology，human papillomavirus(HPV) test，correlation to previous hysterectomy and cervical intraepithelial neoplasia，diagnosis and treatments are analyzed respectively. Results: The patients ranged from 29 to 76(median 48)years old 26 cases shown specific clinical manifestation，in 25 patients the VAIN lesions were located in the upper of the vagina，27 cases had abnomal cytology，23 patients had positive HPV infection.15 cases had a history of hysterectomy，10 of them were cervical intraepithelial neoplasia or invasive cervical cancer.The average interval of the VAIN occurrence after hysterectomy with or without cervical disease was 3.1 years and 8.8 years respectively.10 patients were accompanied with cervical intraepithelial neoplasia and cervical cancer.There were no different significant between VAINⅡ and VAINⅢ in age，hysterectomy，accompanied cervical disease，TCT.All cases were treated by surgery，3 cases recurred. Conclusions: Human papillomavirus infection，cervical intraepithelial neoplasia and cervical cancer，previous hysterectomy due to CIN/cervical cancer were risk factors of VAIN.Cytology(HPV DNA test)colposcopic biopsiespathological diagnosis are very important in diagnosis and followup for vaginal intraepithelial neoplasia，after the treatment of CIN/cervical cancer，strict followup are needed，especially the first 3 years.

Key words: vaginal intraepithelial neoplasia, human papillomavirus, cervical intraepithelial neoplasia