中国实用妇科与产科杂志

中国实用妇科与产科杂志

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上皮性卵巢癌160例预后相关因素分析

杜俊瑶1，杜振广2，常璐3，饶珺3，李联昆1   

  1. 作者单位：1.辽宁省肿瘤医院妇科，辽宁 沈阳110042；2.辽宁省人民医院骨肿瘤科，辽宁 沈阳110016；3.大连医科大学研究生院，辽宁 大连116044
  • 出版日期:2014-06-02 发布日期:2014-05-22
  • 基金资助:

    辽宁省博士启动基金资助（20101058）

 Analysis of prognostic factors of 160 cases with epithelial ovarian cancer.

DU Jun-yao*,DU Zhen-guang,CHANG Lu,RAO Jun,LI Lian-kun*..   

  1. *Department of Gynecology,Liaoning Provincial Cancer Hospital,Shenyang 110042,China
  • Online:2014-06-02 Published:2014-05-22

摘要：

目的 探讨上皮性卵巢癌的预后相关因素及5年生存率。方法 回顾性分析2006年1月至2007年12月辽宁省肿瘤医院初治的上皮性卵巢癌患者160例的临床资料。结果 单因素分析筛选出产次、手术分期、腹膜转移、残余瘤大小、化疗疗程、铂类敏感及化疗后CA125水平与卵巢癌的预后相关（P<0.05）。以手术分期Ⅳ期患者的死亡风险为1，则Ⅰ、Ⅱ、Ⅲ期患者的死亡风险分别为0.164、0.175、0.359，95%CI分别为0.035～0.775、0.037～0.820、0.184～0.704（P<0.05）；术后化疗疗程≥6个疗程患者的死亡风险为＜6个疗程的0.368倍，95%CI为0.209～0.647（P<0.01）；铂类不敏感患者的死亡风险为敏感的4.434倍，95%CI为2.454～8.012（P<0.01）；治疗后CA125水平＞35 kU/L患者的死亡风险为≤35 kU/L的2.062倍，95%CI为1.190～3.572（[WTBX]P[WTBZ]=0.01）。结论 手术分期、化疗疗程、铂类敏感及化疗后CA125水平是上皮性卵巢癌的独立预后因素。

关键词: 卵巢肿瘤, 预后, 5年生存率

Abstract:

Abstract:Objective To assess prognostic factors impacted on overall survival in patients with epithelial ovarian carcinoma．Methods Totally 160 patients with stages I-IV epithelial ovarian carcinoma admitted in Liao-ning Provincial Cancer Hospital from Jan. 2006 to Dec. 2007 were analyzed by retrospective analysis．Results The prognosis of epithelial ovarian carcinomas were related to the number of labors，stage, peritoneal metastasis, the size of residues lesions, the number of courses of chemotherapy, sensitivity to platinum and the level of CA125 after 2-3 courses of chemotherapy (P<0．05).Compared with stage Ⅳ, the risk of mortality was 0.164 for stage Ⅰ(95%CI 0.035-0.775),0.175 for stage Ⅱ(95%CI 0.037-0.820),0.359 (95%CI 0.184-0.704 ) for stage Ⅲ ([WTBX]P[WTBZ]<0.05). The risk of mortality was 0.368，(95%CI 0.209~0.647) for the patients received ≥6 courses of chemotherapy,in comparison with patients received ＜6 courses of chemotherapy（P<0.01）.The risk of mortality in the patients insensitive to platinum was 4.434 times higher than that in patients sensitive to platinum (95%CI 2.454-8.012, P<0.01). The risk of mortality in the patients of serum CA125＞35 kU/L after 2-3 courses of chemotherapy was 2.062 times higher than that in patients CA125≤35 kU/L (95%CI 1.190-3.572,[WTBX]P[WTBZ]=0.01).Conclusion The major independent prognostic factor of epithelial ovarian carcinoma is stage， the number of course of chemotherapy，sensitivity to platinum and the level of CA125 after 2-3 courses of chemotherapy.

Key words: ovarian cancer, prognosis, survival rate of five years

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