干燥综合征是一种主要累及全身外分泌腺体的慢性炎症性自身免疫病。该病总体预后良好，但在妊娠期间可能影响并导致流产、早产、小于胎龄儿和剖宫产率增加，以及胎儿先天性房室传导阻滞、新生儿狼疮、新生儿血色病等先天异常发生。同时对干燥综合征基础疾病与妊娠的相互影响及管理要点做一系统阐述。

Abstract:Sjögren’s syndrome is a major chronic inflammatory autoimmune disease involving systemic exocrine glands. The prognosis of this disease is good in general , but during the pregnancy it may lead to miscarriage, premature birth, IUGR and increasing cesarean section rate, and can also lead to fetal congenital atrioventricular block, neonatal lupus and neonatal blood diseases. The author made a systematic discussion on the interaction between Sjögren’s syndrome and pregnancy ,and key points of management system in this paper.