类风湿性关节炎是一种自身免疫性疾病，在妊娠期，疾病症状有所缓解，而在产后加重，这种现象可能是多种机制作用的结果。妊娠期抗风湿药物的使用受到限制,其用药应依据病情活动性和避免对母儿的毒副反应进行，非甾体抗炎药、柳氮磺胺吡啶、羟氯喹和肿瘤坏死因子（TNF）抑制剂由于被证明在妊娠期使用较安全，可以用来治疗妊娠合并类风湿性关节炎。

Abstract:Rheumatoid arthritis is a kind of autoimmune disorder. The improvement of RA during pregnancy can be attributed to not just a single mechanism but most likely several different pathogenic mechanisms. The use of medication is restricted and should be based on activity of RA and the risk for embryotoxicity and teratogenicity in the offspring should be avoided.Increasing evidence is available on the safe use of NSAIDs,SSZ,HCQ and TNF inhibitors in pregnancy,which can be used in the treatment of pregnancy with RA.