辅助生殖技术静脉血栓栓塞症风险评估及预防中国专家共识(2026年版)

中华预防医学会生育力保护分会, 中国研究型医院学会血栓与止血专业委员会, 中国研究型医院学会妇产科学专业委员会, 北京医师协会生殖医学专业委员会

中国实用妇科与产科杂志 ›› 2026, Vol. 42 ›› Issue (1) : 70-75.

PDF(1033 KB)
PDF(1033 KB)
中国实用妇科与产科杂志 ›› 2026, Vol. 42 ›› Issue (1) : 70-75. DOI: 10.19538/j.fk2026010116
专家共识

辅助生殖技术静脉血栓栓塞症风险评估及预防中国专家共识(2026年版)

作者信息 +
文章历史 +

引用本文

导出引用
中华预防医学会生育力保护分会, 中国研究型医院学会血栓与止血专业委员会, 中国研究型医院学会妇产科学专业委员会, . 辅助生殖技术静脉血栓栓塞症风险评估及预防中国专家共识(2026年版)[J]. 中国实用妇科与产科杂志. 2026, 42(1): 70-75 https://doi.org/10.19538/j.fk2026010116
中图分类号: R169.1   

参考文献

[1]
Dyer S, Chambers GM, Jwa SC, et al. International Committee for Monitoring Assisted Reproductive Technologies world report:assisted reproductive technology,2019[J]. Fertil Steril, 2025, 124(4):679-693. DOI:10.1016/j.fertnstert.2025.06.003.
[2]
Kong F, Wang Y, Li R, et al. Assisted reproductive technology in China:introduction to the special issue[J]. Hum Reprod, 2023, 38(38 Suppl 2):ii1-ii2. DOI:10.1093/humrep/dead215.
[3]
Goualou M, Noumegni S, de Moreuil C, et al. Venous thromboembolism associated with assisted reproductive technology:a systematic review and meta-analysis[J]. Thromb Haemost, 2023, 123(3):283-294. DOI:10.1055/s-0042-1760255.
[4]
Kourlaba G, Relakis J, Kontodimas S, et al. A systematic review and meta-analysis of the epidemiology and burden of venous thromboembolism among pregnant women[J]. Int J Gynaecol Obstet, 2016, 132(1):4-10. DOI:10.1016/j.ijgo.2015.06.054.
[5]
Cresswell JA, Alexander M, Chong MYC, et al. Global and regional causes of maternal deaths 2009-2020:a WHO systematic analysis[J]. Lancet Glob Health, 2025, 13(4):e626-e634. DOI:10.1016/S2214-109X(24)00560-6.
[6]
中华医学会妇产科学分会产科学组. 妊娠期及产褥期VTE预防和诊治专家共识[J]. 中华妇产科杂志, 2021, 56(4):236-243. DOI:10.3760/cma.j.cn112141-20201110-00826.
[7]
上海市母婴安全专家委员会, 上海市医学会围产医学专科分会, 上海市医学会妇产科专科分会产科学组, 等. 上海市产科静脉血栓栓塞症防治的专家共识[J]. 上海医学, 2020, 43(11):645-650. DOI:10.19842j.cnki.issn.0253-9934.2020.11.001.
[8]
RCOG. Reducing the Risk of Thrombosis and Embolism during Pregnancy and the Puerperium (Green-top Guideline No. 37a)[EB/OL].( 2025-04-13)[2025-11-01]. https://www.rcog.org.uk/guidance/browse-all-guidance/green-top-guidelines/reducing-the-risk-of-thrombosis-and-embolism-during-pregnancy-and-the-puerperium-green-top-guideline-no-37a/.
[9]
Queensland Health. Queensland Clinical Guidelines: VTE prophylaxis in pregnancy and the puerperium[EB/OL].( 2025-09-01)[2025-11-01]. https://www.health.qld.gov.au/qcg.
[10]
Balachandren N, Seshadri S, Yasmin E, et al. Venous thromboembolism associated with medically assisted reproduction (MAR):British fertility society policy and practice guidance for assessment and prevention[J]. Hum Fertil (Camb), 2024, 27(1):2352387. DOI:10.1080/14647273.2024.2352387.
[11]
Rova K, Passmark H, Lindqvist PG. Venous thromboembolism in relation to in vitro fertilization:an approach to determining the incidence and increase in risk in successful cycles[J]. Fertil Steril, 2012, 97(1):95-100. DOI:10.1016/j.fertnstert.2011.10.038.
[12]
Luo X, Shan D, Zhang L, et al. Incidence of maternal venous thromboembolism in China:A systematic review and meta-analysis[J]. Int J Gynaecol Obstet, 2023, 163(1):75-88. DOI:10.1002/ijgo.14776.
[13]
Goualou M, Noumegni S, de Moreuil C, et al. Venous thromboembolism associated with assisted reproductive technology:a systematic review and meta-analysis[J]. Thromb Haemost, 2023, 123(3):283-294.DOI:10.1055/s-0042-1760255.
[14]
Gregson J, Kaptoge S, Bolton T, et al. Cardiovascular risk factors associated with venous thromboembolism[J]. JAMA Cardiol, 2019, 4(2):163-173. DOI:10.1001/jamacardio.2018.4537.
[15]
Cheng YJ, Liu ZH, Yao FJ, et al. Current and former smoking and risk for venous thromboembolism:a systematic review and meta-analysis[J]. PLoS Med, 2013, 10(9):e1001515. DOI:10.1371/journal.pmed.1001515.
[16]
Mi Y, Yan S, Lu Y, et al. Venous thromboembolism has the same risk factors as atherosclerosis:a PRISMA-compliant systemic review and meta-analysis[J]. Medicine (Baltimore), 2016, 95(32):e4495. DOI:10.1097/MD.0000000000004495.
[17]
Ageno W, Becattini C, Brighton T, et al. Cardiovascular risk factors and venous thromboembolism:a meta-analysis[J]. Circulation, 2008, 117(1):93-102. DOI:10.1161/CIRCULATIONAHA.107.709204.
[18]
Sultan AA, Tata LJ, West J, et al. Risk factors for first venous thromboembolism around pregnancy:a population-based cohort study from the United Kingdom[J]. Blood, 2013, 121(19):3953-3961. DOI:10.1182/blood-2012-11-469551.
[19]
Provencher S, Nassiri Kigloo H, Mai V, et al. Polycystic ovary syndrome,endometriosis,and venous thromboembolism:a population-based study[J]. Gynecol Obstet Invest, 2025, 90(6):603-610. DOI:10.1159/000545518.
[20]
Bello N, Meyers KJ, Workman J, et al. Systematic literature review and meta-analysis of venous thromboembolism events in systemic lupus erythematosus[J]. Rheumatol Ther, 2023, 10(1):7-34. DOI:10.1007/s40744-022-00513-1.
[21]
Aviña-Zubieta JA, Jansz M, Sayre EC, et al. The risk of deep venous thrombosis and pulmonary embolism in primary Sjögren syndrome:a general population-based study[J]. J Rheumatol, 2017, 44(8):1184-1189. DOI:10.3899/jrheum.160185.
[22]
Yanru Hou, Li Tian, Huai Feng. Fertility preservation for female patients with childhood and adolescent cancer[J]. GOCM, 2022, 2022(4):161-163. DOI:10.1016/j.gocm.2022.11.002.
[23]
Key NS, Khorana AA, Kuderer NM, et al. Venous thromboembolism prophylaxis and treatment in patients with cancer:ASCO clinical practice guideline update[J]. J Clin Oncol, 2020, 38(5):496-520. DOI:10.1200/JCO.19.01461.
[24]
Melo VD, Liseth OY, Schmidt WM, et al. Risk of thrombosis in women with cancer undergoing controlled ovarian hyperstimulation for fertility preservation[J]. J Assist Reprod Genet, 2022, 39(12):2847-2856. DOI:10.1007/s10815-022-02661-3.
[25]
Bistervels IM, Buchmüller A, Wiegers HMG, et al. Intermediate-dose versus low-dose low-molecular-weight heparin in pregnant and post-partum women with a history of venous thromboembolism (Highlow study):an open-label,multicentre,randomised,controlled trial[J]. Lancet, 2022, 400(10365):1777-1787. DOI:10.1016/S0140-6736(22)02128-6.
[26]
中华医学会血液学分会血栓与止血学组. 易栓症诊断与防治中国指南(2021年版)[J]. 中华血液学杂志, 2021, 42(11):881-888. DOI:10.3760/cma.j.issn.0253-2727.2021.11.001.
[27]
Zöller B, Li X, Ohlsson H, et al. Family history of venous thromboembolism as a risk factor and genetic research tool[J]. Thromb Haemost, 2015, 114(5):890-900. DOI:10.1160/TH15-04-0306.
[28]
Goodwin AJ, Rosendaal FR, Kottke-Marchant K, et al. A review of the technical,diagnostic,and epidemiologic considerations for protein S assays[J]. Arch Pathol Lab Med, 2002, 126(11):1349-1366. DOI:10.5858/2002-126-1349-AROTTD.
[29]
American College of Obstetricians and Gynecologists' Committee on Practice Bulletins-Obstetrics. ACOG Practice Bulletin No. 197:Inherited Thrombophilias in Pregnancy[J]. Obstet Gynecol, 2018, 132(1):e18-e34. DOI:10.1097/AOG.0000000000002703.
[30]
Rhéaume M, Weber F, Durand M, et al. Pregnancy-related venous thromboembolism risk in asymptomatic women with antithrombin deficiency:a systematic review[J]. Obstet Gynecol, 2016, 127(4):649-656. DOI:10.1097/AOG.0000000000001347.
[31]
Friederich PW, Sanson BJ, Simioni P, et al. Frequency of pregnancy-related venous thromboembolism in anticoagulant factor-deficient women:implications for prophylaxis[J]. Ann Intern Med, 1996, 125(12):955-960. DOI:10.7326/0003-4819-125-12-199612150-00003.
[32]
Croles FN, Nasserinejad K, Duvekot JJ, et al. Pregnancy,thrombophilia,and the risk of a first venous thrombosis:systematic review and bayesian meta-analysis[J]. BMJ, 2017,359:j4452. DOI:10.1136/bmj.j4452.
[33]
中国妇幼保健协会出生缺陷防治与分子遗传分会, 儿童早期发展专委会, 儿童疾病和保健分会遗传代谢学组, 等. 高同型半胱氨酸血症的诊断、治疗与预防专家共识[J]. 罕少疾病杂志, 2022, 29(6):1-4. DOI:10.3969/j.issn.1009-3257.2022.06.001.
[34]
Den Heijer M, Lewington S, Clarke R. Homocysteine, MTHFR and risk of venous thrombosis:a meta-analysis of published epidemiological studies[J]. J Thromb Haemost, 2005, 3(2):292-299. DOI:10.1111/j.1538-7836.2005.01141.x.
[35]
Miyakis S, Lockshin MD, Atsumi T, et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS)[J]. J Thromb Haemost, 2006, 4(2):295-306. DOI:10.1111/j.1538-7836.2006.01753.x.
[36]
Cervera R, Serrano R, Pons-Estel GJ, et al. Morbidity and mortality in the antiphospholipid syndrome during a 10-year period:a multicentre prospective study of 1000 patients[J]. Ann Rheum Dis, 2015, 74(6):1011-1018. DOI:10.1136/annrheumdis-2013-204838.
[37]
de Jesús GR, Sciascia S, Andrade D, et al. Factors associated with first thrombosis in patients presenting with obstetric antiphospholipid syndrome (APS) in the APS alliance for clinical trials and international networking clinical database and repository:a retrospective study[J]. BJOG, 2019, 126(5):656-661. DOI:10.1111/1471-0528.15469.
[38]
Ruffatti A, Del Ross T, Ciprian M, et al. Risk factors for a first thrombotic event in antiphospholipid antibody carriers:a prospective multicentre follow-up study[J]. Ann Rheum Dis, 2011, 70(6):1083-1086. DOI:10.1136/ard.2010.142042.
[39]
Abou-Ismail MY, Citla Sridhar D, Nayak L. Estrogen and thrombosis: A bench to bedside review[J]. Thromb Res, 2020, 192:40-51. DOI:10.1016/j.thromres.2020.05.008.
[40]
Magnusson Å, Källen K, Thurin-Kjellberg A, Bergh C. The number of oocytes retrieved during IVF:a balance between efficacy and safety[J]. Hum Reprod, 2018, 33(1):58-64. DOI:10.1093/humrep/dex334.
[41]
中华医学会生殖医学分会. 辅助生殖技术并发症诊断及处理共识[J]. 生殖与避孕, 2015, 35(7):431-439. DOI:10.7669/j.issn.0253-357X.2015.07.0431.
[42]
李东言, 魏玉梅. 围产期静脉血栓栓塞症的预防与处理[J]. 中国实用妇科与产科杂志, 2025, 41(6):614-618. DOI:10.19538/j.fk2025060109.
[43]
Jacobsen AF, Skjeldestad FE, Sandset PM. Incidence and risk patterns of venous thromboembolism in pregnancy and puerperium-a register-based case-control study[J]. Am J Obstet Gynecol, 2008, 198(2):233.e1-233.e2337. DOI:10.1016/j.ajog.2007.08.041.
[44]
ESHRE Guideline Group on Ovarian Stimulation,Bosch E, Broer S, et al. Erratum:ESHRE guideline:ovarian stimulation for IVF/ICSI[J]. Hum Reprod Open, 2020, 2020(4): hoaa067. DOI:10.1093/hropen/hoaa067.
[45]
Hignett M, Spence JE, Claman P. Internal jugular vein thrombosis:a late complication of ovarian hyperstimulation syndrome despite mini-dose heparin prophylaxis[J]. Hum Reprod, 1995, 10(12):3121-3123. DOI:10.1093/oxfordjournals.humrep.a135870.
[46]
国家妇幼健康研究会生殖免疫学专业委员会专家共识编写组. 复发性流产抗血栓药物治疗中国专家共识[J]. 中华生殖与避孕杂志, 2022, 42(12):1207-1217. DOI:10.3760/cma.j.cn101441-20220907-00385.2022,42(12).

脚注

利益冲突 专家组成员均声明不存在利益冲突

基金

国家重点研发计划(2022YFC2704400)
四川省科技厅重点研发项目(2024YFFK0076)
四川省科技厅重点研发项目(2024YFFK0366)

PDF(1033 KB)

Accesses

Citation

Detail

段落导航
相关文章

/