子宫颈癌诊治规范化中的个体化

陈春林, 毛东瑞, 陈晓林, 刘燕

中国实用妇科与产科杂志 ›› 2026, Vol. 42 ›› Issue (1) : 19-24.

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中国实用妇科与产科杂志 ›› 2026, Vol. 42 ›› Issue (1) : 19-24. DOI: 10.19538/j.fk2026010105
专题笔谈

子宫颈癌诊治规范化中的个体化

作者信息 +

Individualization in the standardized diagnosis and treatment of cervical cancer

Author information +
文章历史 +

摘要

子宫颈癌诊疗需在规范化基础上融入个体化理念。通过分子分型、分子标志物检测、影像精准导航及复发预测模型,实现从筛查、手术到随访的全流程精准管理,从而提升疗效并改善患者预后。

Abstract

The diagnosis and treatment of cervical cancer requires the integration of individualized approaches in a standardized framework. The techniques such as molecular subtyping,molecular marker testing,image-guided navigation,and recurrence prediction models are used to achieve precise,end-to-end management from screening and surgery to follow-up. This comprehensive strategy aims to enhance therapeutic efficacy and improve patient prognosis.

关键词

子宫颈癌前病变 / 子宫颈癌 / 诊治 / 规范化 / 个体化

Key words

cervical intraepithelial neoplasia / cervical cancer / diagnosis and treatment / standardization / individualization

引用本文

导出引用
陈春林, 毛东瑞, 陈晓林, . 子宫颈癌诊治规范化中的个体化[J]. 中国实用妇科与产科杂志. 2026, 42(1): 19-24 https://doi.org/10.19538/j.fk2026010105
CHEN Chun-lin, MAO Dong-rui, CHEN Xiao-lin, et al. Individualization in the standardized diagnosis and treatment of cervical cancer[J]. Chinese Journal of Practical Gynecology and Obstetrics. 2026, 42(1): 19-24 https://doi.org/10.19538/j.fk2026010105
中图分类号: R737.3   

参考文献

[1]
Simms KT, Steinberg J, Caruana M, et al. Impact of scaled up human papillomavirus vaccination and cervical screening and the potential for global elimination of cervical cancer in 181 countries,2020-99:a modelling study[J]. Lancet Oncol, 2019, 20(3):394-407. DOI:10.1016/S1470-2045(18)30836-2.
[2]
Bonde J, Floore A, Ejegod D, et al. Methylation markers FAM19A4 and miR124-2 as triage strategy for primary human papillomavirus screen positive women:A large European multicenter study[J]. Int J Cancer, 2021, 148(2):396-405. DOI:10.1002/ijc.33320.
[3]
Wentzensen N, Clarke MA, Bremer R, et al. Clinical evaluation of human papillomavirus screening with p16/Ki-67 dual stain triage in a large organized cervical cancer screening program[J]. JAMA Intern Med, 2019, 179(7):881-888. DOI:10.1001/jamainternmed.2019.0306.
[4]
Li C, Wu H, Guo L, et al. Single-cell transcriptomics reveals cellular heterogeneity and molecular stratification of cervical cancer[J]. Commun Biol, 2022, 5(1):1208. DOI:10.1038/s42003-022-04142-w.
[5]
Huang RSP, Haberberger J, Murugesan K, et al. Clinicopathologic and genomic characterization of PD-L1-positive uterine cervical carcinoma[J]. Mod Pathol, 2021, 34(7):1425-1433. DOI:10.1038/s41379-021-00780-3.
[6]
Yang X, Zhu W. ERBB3 mediates the PI3K/AKT/mTOR pathway to alter the epithelial‑mesenchymal transition in cervical cancer and predict immunity filtration outcome[J]. Exp Ther Med, 2023, 25(4):146. DOI:10.3892/etm.2023.11845.
[7]
Zou R, Chen X, Jin X, et al. Up-regulated BCAR4 contributes to proliferation and migration of cervical cancer cells[J]. Surg Oncol, 2018, 27(2):306-313. DOI:10.1016/j.suronc.2018.05.013.
[8]
Rakha EA, Quinn C, Masannat YA, et al. Revisiting surgical margins for invasive breast cancer patients treated with breast conservation therapy - Evidence for adopting a 1 mm negative width[J]. Eur J Surg Oncol, 2024, 50(10):108573. DOI:10.1016/j.ejso.2024.108573.
[9]
中华医学会肿瘤学会结直肠肿瘤学组. 直肠癌外科手术切缘中国专家共识(2024版)[J]. 中华胃肠外科杂志, 2024, 27(6):545-558. DOI:10.3760/cma.j.cn441530-20240403-00123.
[10]
余未, 梁骏, 杨振云, 等. 初始不可切除肝细胞癌经转化治疗后手术切缘宽度安全阈值分析[J]. 中国普通外科杂志, 2025, 34(9):1987-1995. DOI:10.7659/j.issn.1005-6947.250307.
[11]
Salib MY, Russell JHB, Stewart VR, et al. 2018 FIGO Staging Classification for Cervical Cancer:Added Benefits of Imaging[J]. Radiographics,2020, 40(6):1807-1822. DOI:10.1148/rg.2020200013.
[12]
Shinagare AB, Burk KS, Kilcoyne A, et al. ACR Appropriateness Criteria® Pretreatment Evaluation and Follow-Up of Invasive Cancer of the Cervix:2023 Update[J]. J Am Coll Radiol, 2024, 21(6S):S249-S267. DOI:10.1016/j.jacr.2024.02.026.
[13]
Manganaro L, Lakhman Y, Bharwani N, et al. Staging,recurrence and follow-up of uterine cervical cancer using MRI:Updated Guidelines of the European Society of Urogenital Radiology after revised FIGO staging 2018[J]. Eur Radiol, 2021, 31(10):7802-7816. DOI:10.1007/s00330-020-07632-9.
[14]
Liu B, Gao S, Li S. A Comprehensive comparison of CT,MRI,positron emission tomography or positron emission tomography/CT,and diffusion weighted imaging-MRI for detecting the lymph nodes metastases in patients with cervical cancer:a meta-analysis based on 67 studies[J]. Gynecol Obstet Invest, 2017, 82(3):209-222. DOI:10.1159/000456006.
[15]
Fan X, Liu X, Xia Q, et al. Advanced Image-guidance and surgical-navigation techniques for real-time visualized surgery[J]. Adv Sci (Weinh), 2025, 12(41):e09294. DOI:10.1002/advs.202509294.
[16]
Chen X, Duan H, Liu P, et al. Development and validation of a prognostic nomogram for 2018 FIGO stages ⅠB1,ⅠB2,and ⅡA1 cervical cancer:a large multicenter study[J]. Ann Transl Med,2022, 10(2):121. DOI:10.21037/atm-21-6367.
[17]
Manzour N, Chiva L, Chacón E, et al. SUCCOR risk:design and validation of a recurrence prediction index for early-stage cervical cancer[J]. Ann Surg Oncol, 2022, 29(8):4819-4829. DOI:10.1245/s10434-022-11671-5.
[18]
Cibula D, Dostálek L, Jarkovsky J, et al. The annual recurrence risk model for tailored surveillance strategy in patients with cervical cancer[J]. Eur J Cancer, 2021, 158:111-122. DOI:10.1016/j.ejca.2021.09.008.
[19]
陈春林, 段慧. 应客观评价微无创技术在妇产科疾病诊治中的应用[J]. 中国实用妇科与产科杂志, 2024, 40(9):913-917. DOI:10.19538/j.fk2024090114.
[20]
唐雷, 钟世镇. 人工智能及其在医学领域中的应用[J]. 中国实用妇科与产科杂志, 2024, 40(9):876-878. DOI:10.19538/j.fk2024090104.
[21]
陈春林, 李朋飞, 陈晓林. 微无创与人工智能的融合:妇产科疾病诊治的未来[J]. 中国实用妇科与产科杂志, 2024, 40(9):867-871. DOI:10.19538/j.fk2024090102.
[22]
陈春林, 蒋冰阳. 妇科恶性肿瘤微创手术中的无瘤防御[J]. 中国实用妇科与产科杂志, 2023, 39(1):10-13. DOI:10.19538/j.fk2023010103.

脚注

利益冲突 作者声明不存在利益冲突

基金

国家重点研发计划(2021YFC2701402)
国家自然科学基金(82371655)
国家自然科学基金(82101701)
南京医科大学姑苏学院引进人才项目(GSRCKY20250102)
苏州市立医院“科教兴卫”专项资金新引进人才项目(Szslyyrc202503001)

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