妇科术后出血行超选择性动脉栓塞术介入治疗临床疗效分析

褚丹霞, 禇金蒙, 张建好, 吴杰, 来天娇, 陈志华, 郭瑞霞

中国实用妇科与产科杂志 ›› 2025, Vol. 41 ›› Issue (4) : 466-469.

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中国实用妇科与产科杂志 ›› 2025, Vol. 41 ›› Issue (4) : 466-469. DOI: 10.19538/j.fk2025040117
论著

妇科术后出血行超选择性动脉栓塞术介入治疗临床疗效分析

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Clinical diagnosis and treatment analysis of postoperative gynecologic hemorrhage undergoing super-selective arterial embolization intervention

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摘要

目的 探讨超选择性动脉栓塞术在妇科手术后出血中的应用价值。方法 2013年5月至2020年5月在郑州大学第一附属医院对15例经保守治疗无效的妇科术后出血患者行动脉造影,明确出血部位后应用聚乙烯醇颗粒加明胶海绵进行动脉栓塞术,分析其治疗效果。结果 15例患者经超选择性动脉栓塞术后均在48h内停止出血,其中7例患者出血立即停止;8例患者仍有少量出血,其中2例患者在12h内出血逐渐停止,4例患者在24h内出血逐渐停止,2例患者在48h内出血逐渐停止,止血有效率达100%。术后仅有发热、下腹及臀部疼痛等轻微并发症,经对症处理后症状均缓解。结论 超选择性动脉栓塞术是治疗妇科术后出血的有效方法,不仅避免了患者承受二次手术及麻醉的风险,而且增加了保留子宫的概率,可作为妇科术后止血的优选方法。

Abstract

Objective To investigate the value of super-selective arterial embolization in bleeding after gynecologic surgery. Methods From May 2013 to May 2020 at the First Affiliated Hospital of Zhengzhou University,15 patients with postoperative gynecological hemorrhage,for whom conservative treatment was ineffective,underwent arteriography;after the hemorrhage site was clarified,the polyvinyl alcohol particles plus gelatin sponge was applied for embolization,and its therapeutic effect was analyzed. Results After super-selective arterial embolization,bleeding stopped within 48 h in all 15 patients,among which bleeding stopped immediately in 7 patients;8 patients still had a small amount of bleeding: bleeding gradually stopped within 12 h in 2 patients,bleeding gradually stopped within 24 h in 4 patients,and bleeding gradually stopped within 48 h in 2 patients. The hemostatic efficiency of the patients reached 100%. There were only mild postoperative complications such as fever,lower abdominal and hip pain,all of which were relieved with symptomatic management. Conclusion Super-selective arterial embolization is an effective method of treating postoperative gynecological bleeding,which not only avoids the risk of a second surgery and anesthesia endured by the patient,but also increases the chance of uterine preservation. Therefore,it can be used as a preferred method of hemostasis after gynecological surgery.

关键词

动脉栓塞术 / 妇科术后出血 / 保留子宫 / 动脉造影

Key words

arterial embolization / postoperative gynecologic bleeding / uterine preservation / arteriography

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褚丹霞, 禇金蒙, 张建好, . 妇科术后出血行超选择性动脉栓塞术介入治疗临床疗效分析[J]. 中国实用妇科与产科杂志. 2025, 41(4): 466-469 https://doi.org/10.19538/j.fk2025040117
CHU Dan-xia, CHU Jin-meng, ZHANG Jian-hao, et al. Clinical diagnosis and treatment analysis of postoperative gynecologic hemorrhage undergoing super-selective arterial embolization intervention[J]. Chinese Journal of Practical Gynecology and Obstetrics. 2025, 41(4): 466-469 https://doi.org/10.19538/j.fk2025040117
中图分类号: R713.1   

参考文献

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A case of severe postpartum hemorrhage is reported. Three separate surgical procedures failed to reveal the source of bleeding, and standard surgical techniques, including bilateral ligation of the hypogastric arteries, were unsuccessful in producing hemostasis. However, angiography successfully identified the specific bleeding vessel, and transcatheter embolization with Gelfoam fragments quickly and effectively stopped the hemorrhage. The authors consider angiographic embolization to be an effective alternative approach to the control of pelvic hemorrhage and recommend that the technique be considered prior to surgical intervention.
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Introduction: Postpartum hemorrhage (PPH) is the leading cause of peripartal maternal mortality and accounts for 25% of all maternal deaths worldwide. The most common reasons of PPH are uterine atony, retained placenta, or placenta accreta spectrum. Treatment of PPH depends on the etiology and corresponds to a stepwise approach, which follows the German, Austrian and Swiss guideline for the diagnosis and therapy of PPH in Switzerland. In severe ongoing PPH, hysterectomy has been the ultima ratio for many decades. Nowadays, interventional embolization of the pelvic arteries (PAE) has become a popular alternative. Besides being a highly effective minimally invasive method, PAE avoids hysterectomy with consecutively reduced morbidity and mortality. However, data on the long-term effects of PAE on fertility and menstrual cycle are scarce. Methods: We performed a monocentric study consisting of a retro- and a prospective part including all women who had undergone a PAE between 2012 and 2016 at University Hospital Zurich. Descriptive characteristics of patients and efficacy of PAE defined as cessation of bleeding were analyzed retrospectively. In the prospective part, all patients were contacted for a follow-up questionnaire regarding menstruation and fertility after embolization. Results: Twenty patients with PAE were evaluated. Our data showed a success rate of PAE in 95% of patients with PPH; only 1 patient needed a second, then successful, PAE. No patient needed a hysterectomy or any other surgical intervention. In our study, an association between mode of delivery and identified etiology of PPH is observed. After spontaneous delivery (n = 6), the main reason of severe PPH was retained placenta (n = 4), while after cesarean section (n = 14), uterine atony was identified in most cases (n = 8). Regarding menstruation after embolization, all women reported regular menstruation after the breastfeeding period (100%). The majority reported a regular pattern with a shorter or similar duration (73%) and lower or similar intensity (64%). Dysmenorrhea decreased in 67% of patients. Four patients planned another pregnancy, of whom only one had become pregnant with assisted reproductive technology and ended up in a miscarriage. Discussion: Our study confirms the efficacy of PAE in PPH, thus obviating complex surgical interventions and associated morbidity. The success of PAE does not depend on the primary cause of PPH. Our results may encourage the prompt decision to perform PAE in the management of severe PPH in case of failure of conservative management and help physicians in the post-interventional counseling regarding menstruation patterns and fertility.
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To evaluate the outcomes of uterine artery embolization (UAE) for patients with urgent or emergent abnormal uterine bleeding (AUB).Retrospective review of all patients from 1/2009-12/2020 who were treated urgently or emergently with UAE for AUB. Urgent and emergent cases were defined as those requiring inpatient admissions. Demographic data were collected for each patient including hospitalizations related to bleeding and length of stay (LOS) for each hospitalization. Hemostatic interventions other than UAE were collected. Hematologic data were collected before and after UAE including hemoglobin, hematocrit, and transfusion products. Data specific to the UAE procedure included complication rates, 30-day readmission, 30-day mortality, embolic agent, site of embolization, radiation dose, and procedure time.52 patients (median age: 39) underwent 54 urgent or emergent UAE procedures. The most common indications for UAE were malignancy (28.8%), post-partum hemorrhage (21.2%), fibroids (15.4%), vascular anomalies (15.4%), and post-operative bleeding (9.6%). There were no procedure-related complications. Following UAE, 44 patients (84.6%) achieved clinical success and required no additional intervention. Packed red blood cell transfusion decreased from a mean of 5.7 to 1.7 units (p < 0.0001). Fresh frozen plasma transfusion decreased from a mean of 1.8 to 0.48 units (p = 0.012). 50% of patients received a transfusion prior to UAE, while only 15.4% were transfused post-procedure (p = 0.0001).Emergent or urgent UAE is a safe and effective procedure to control AUB hemorrhage secondary to a variety of etiologies.© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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河南省卫健委省部共建重点项目(SBGJ202302074)

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