复杂性双胎并发症发病机制研究进展

龚娥; 王岚; 漆洪波; 丁裕斌

doi:10.19538/j.fk2025020105

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中国实用妇科与产科杂志 ›› 2025, Vol. 41 ›› Issue (2) : 147-154. DOI: 10.19538/j.fk2025020105

专题笔谈

复杂性双胎并发症发病机制研究进展

龚娥 ¹ ,
王岚 ¹ ,
漆洪波 ² ,
丁裕斌 ³

作者信息 +

Rearch progress in the pathogenesis of complicated twin complications

E GONG ¹ ,
Lan WANG ¹ ,
Hong-bo QI ² ,
Yu-bin DING ³

Author information +

文章历史 +

摘要

单绒毛膜双胎在双胎妊娠中占比约30%，易出现包括双胎输血综合征（TTTS）、选择性胎儿生长受限（sFGR）等多种复杂性双胎并发症，可导致出生缺陷、早产等不良结局。复杂性双胎并发症的发病机制涉及胎盘解剖结构异常、血流动力学紊乱、分子生物学及遗传学因素等多个方面。近年来国内外学者在该领域的研究取得了一定进展，例如关于胎盘血管吻合等方面的研究不断深化、遗传学研究揭示特定基因变异与并发症关联，这为复杂性双胎并发症的早期诊断和治疗奠定了基础。文章综述了复杂性双胎并发症发病机制的研究进展，并探讨了干预策略，以期为临床研究和治疗提供参考。

Abstract

Monochorionic twins，accounting for about 30% of twin pregnancies，are prone to complicated complications such as TTTS and sFGR，which can lead to adverse outcomes，including birth defects，preterm birth and so on. The pathogenesis of these complications involves abnormal placental structures，hemodynamic disorders，molecular biological and genetic factors. In recent years，some advancements have been made in this field at home and abroad. For example，studies on placental vascular anastomosis have been deepened，and genetic studies have revealed the relationship between specific gene mutations and complications，laying a foundation for early diagnosis and treatment of complicated twin complications. This review summarizes the current research progress in the pathogenesis of complicated twin complications and explores intervention strategies，aiming to provide references for further clinical research and treatment.

导出引用

龚娥, 王岚, 漆洪波, 等. 复杂性双胎并发症发病机制研究进展[J]. 中国实用妇科与产科杂志. 2025, 41(2): 147-154 https://doi.org/10.19538/j.fk2025020105

E GONG, Lan WANG, Hong-bo QI, et al. Rearch progress in the pathogenesis of complicated twin complications[J]. Chinese Journal of Practical Gynecology and Obstetrics. 2025, 41(2): 147-154 https://doi.org/10.19538/j.fk2025020105

中图分类号： R714.23

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