Archive

06 April 2019, Volume 34 Issue 4 Previous Issue    Next Issue

---

For Selected:

Download Citations EndNote Ris BibTeX

Toggle Thumbnails

Select

Expert consensus on the safe and rational use of aminophylline in children 2019, 34(4): 249-255.  DOI: 10.19538/j.ek2019040601 Abstract ( )

Select

Chinese expert consensus on the diagnosis and treatment of chronic wet cough in children（2019） Chronic Cough Collaboration Group of Respiration Group of Pediatrics Branch of Chinese Medical Association，Editorial Board of Chinese Journal of Practical Pediatrics 2019, 34(4): 256-264.  DOI: 10.19538/j.ek2019040602 Abstract ( )

Select

Expert consensus on immunization in children with special health state（ⅩⅥ） ——kidney diseases and immunization Center for Disease Control and Prevention in Suzhou，Center for Disease Control and Prevention in Shanghai，Center for Disease Control and Prevention in Hangzhou，et al 2019, 34(4): 265-266.  DOI: 10.19538/j.ek2019040603 Abstract ( )

Select

Expert consensus on immunization in children with special health state（ⅩⅦ）——leukemia chemotherapy and immunization Center for Disease Control and Prevention in Suzhou，Center for Disease Control and Prevention in Shanghai，Center for Disease Control and Prevention in Hangzhou，et al 2019, 34(4): 266-267.  DOI: 10.19538/j.ek2019040604 Abstract ( )

Select

Expert consensus on immunization in children with special health state（ⅩⅧ） ——child anemia and immunization Center for Disease Control and Prevention in Suzhou，Center for Disease Control and Prevention in Shanghai，Center for Disease Control and Prevention in Hangzhou，et al 2019, 34(4): 268-269.  DOI: 10.19538/j.ek2019040605 Abstract ( )

Select

Interpretation of the pharmaceutical part of Expert Consensus on the Safe and Rational Use of Aminophylline in Children LI Zhi-ping*，WANG Guang-fei，ZHU Lin，et al 2019, 34(4): 270-276.  DOI: 10.19538/j.ek2019040606 Abstract ( )   Theophylline is one of the most widely prescribed drugs worldwide for the treatment of asthma and chronic obstructive pulmonary disease（COPD），and it has been used clinically for more than 80 years. Due to the many adverse reactions and narrow therapeutic window，theophylline and its derivatives have gradually become the third or fourth options in clinical treatment of asthma，especially after the application of inhaled glucocorticoids and β2-ceptor agonists in asthma with good therapeutic effect. However，with the further elucidation of asthma pathogenesis and the in-depth study of theophylline’s mechanism of action，as well as the development of specific drug formulations of theophylline such as sustained-release and controlled-release dosage forms，the therapeutic position of theophylline in asthma treatment has been consolidated and understood in a new way. In this paper，the pharmacology and pharmacokinetic parts of "Expert Consensus on the Safe and Rational Use of Aminophylline in Children" are explained in detail，so as to provide reference for rational application of aminophylline in pediatrics.

Select

Understanding “One Health” to actively and steadily promote pediatrician training after graduation ZHAO Zheng-yan， ZOU Chao-chun 2019, 34(4): 277-279.  DOI: 10.19538/j.ek2019040607 Abstract ( )   Medicine is a highly practical science. A high-quality clinical doctor must go through strict college education， post-graduation education and follow-up continuing education. Since the implementation of standardized resident training in 2014， great achievements have been achieved：great attention has been paid to residential training，about 500 pediatric professional training bases have been set up nationwide，and software and hardware（e.g. simulation centers and teacher training） have been upgraded. Since 2017， the state has gradually launched specialty training. In the process of promoting resident and specialty training，some problems were exposed. Hence，pediatrician training needs to be in line with the “top-level design” of national health， such as the system of tiered medical services，and family physician contract system；to handle the phases and continuity of different stages of medical education； to learn foreign excellent experience based on the national conditions of China. With good top-level design， medical and educational collaboration， learning international advanced experience based on our national conditions， a standardized medical training system with Chinese characteristics will be built， which will enhance the overall level of our medical team.

Select

Electrical and clinical study of the synchronous occipital and frontopolar spikes phenomenon YANG Hai-po，LU Jiao-yang，GUAN Qiao，et al 2019, 34(4): 280-283.  DOI: 10.19538/j.ek2019040608 Abstract ( )   Objective　To study the clinical characteristics of epileptic patients with synchronous occipital and frontopolar spikes phenomenon. Methods　The clinical data，EEG features of patients with synchronous occipital and frontopolar spikes phenomenon were retrospectively reviewed. Results　Totally 34 male and 21 female patients had synchronous occipital and frontopolar spikes. Ages at the time of recording the synchronous occipital and frontopolar spikes phenomenon ranged from 2 years 6 months to 14 years with the median age of 6 years 6 months. In the total 55 patients，12 patients had contralateral synchronous discharges，12 patients had ipsilateral synchronous，17 patients had bilateral synchronous discharges，7 patients had bilateral synchronous discharges tending to contralateral synchronously，and 7 patients had bilateral synchronous discharges tending to ipsilateral synchronously. Occipital preceded frontopolar discharges in 42 patients. Frontopolar preceded occipital discharges in 3 patients. The phase difference between the occipital and frontopolar spikes could not be distinguished in 10 patients. Based on the etiology and diagnoses，there was Panayiotopoulos syndrome in 33 patients，epilepsy with structural abnormality in 13 patients，secondary epilepsy due to immune encephalitis in 1 patient，epilepsy accompanied by inborn error of metabolism in 2 patients and epilepsy with unknown etiology in 6 patients. Conclusion　The synchronous occipital and frontopolar spikes phenomenon usually appears during childhood or develops from other discharge patterns in infancy stage. The synchronous occipital and frontopolar spikes phenomenon can be ipsilateral synchronous or contralateral synchronous discharges. The occipital spikes preceded frontopolar spikes in most patients. The synchronous occipital and frontopolar spikes phenomenon is mostly found in Panayiotopoulos syndrome，but it is also found in epilepsy with different etiologies.

Select

Health-related risky behaviors in adolescents with high functioning autism GAO Zi-lin*，LIU Jing，LI Xue，et al 2019, 34(4): 284-289.  DOI: 10.19538/j.ek2019040609 Abstract ( )   Objective　To investigate the characteristics of health-related risky behaviors in adolescents with High Functioning Autism（HFA）. Methods　Fifty adolescents aged 12-18 years，IQ≥70 and meeting the criteria of autistic disorder in Diagnostic and Statistical Manual of Mental Disorders，Fourth Edition（DSM-Ⅳ），and 50 age- and gender- matched healthy controls were recruited. The health-related risky behaviors of all subjects were assessed with the Adolescents Health-related Risky Behavior Inventory（AHRBI）. The parents of autistic subjects completed the Adolescents Health-related Risky Behavior Inventory for Parent（AHRBI-P）. Results　HFA group had higher total scale score and four subscales’ scores of AHRBI than controls，including Suicide and Self-Injury（SS），Health-Compromising Behavior（HCB），Aggression and Violence（AV） and Rule Breaking（RB）（all P＜0.05）. HFA group had higher scores than controls in the items of "Bullying/Threatening/Intimidating partner"，"Deliberately pushing and shoving others"，"Not drinking milk/soy milk"，"Not participating in any form of physical activity"，"Skiping class/Playing truant"，"Running away from home"，"Biting/Scratching/Bumping to hurt oneself"（all P＜0.05）. Among all the subscales and items，the scores of HCB，SS，"Not drinking milk/soy milk"，"Physical discomfort due to dieting"，"Fighting and Arms-taking" and "Drinking" of self-assessment in HFA group were higher than those of parents’ assessment（all P＜0.05］. Conclusion　The adolescents with HFA have more health-related risky behaviors than the healthy adolescents except for Smoking and Drinking（SD） and Unprotected sex（US）.

Select

Etiology of 142 cases of infant cholestasis and the evaluation of the common diagnostic methods　 PAN Su-xiang，WU Bin，CHEN Su-qing，et al 2019, 34(4): 290-294.  DOI: 10.19538/j.ek2019040610 Abstract ( )   Objective　To investigate the etiology of infant cholestasis，and to evaluate the commonly clinical diagnostic methods in diagnosing infant biliary atresia（BA）. Methods　A total of 142 hospitalized children with infant cholestasis in the pediatric ward of our hospital from January 1，2012 to November 30，2016 were included. Results　Totally 99 cases（69.7%） were comfirmed，and the most common causes were BA，cytomegalovirus infection and citrin protein deficiency. Totally 37 cases（26.1%） were diagnosed as idiopathic infant hepatitis and 6 cases（4.2%） were undiagnosed. Compared with no-BA group，acholie stools predominated in BA group，and the serum γ-GT in BA were significantly higher. Abdominal ultrasonography showed that 81.2% were cholecyst undiscovered or small in size in BA. Hepatobiliary scintigraphy（HBS） showed that 95.0% had no image of gallbladder or radioactive concentration in bowel and 5.0% had delayed image or radioactive conceatration in BA. The difference between the two group；was statistical（P＜0.01）. The?sensitivity，specificity，and? accuracy?of?acholic stools to diagnose BA were?91.3%，92.9%， and?92.2%， γ-GT≥300 U/L were?65.2%，91.8%， 83.3%， abdominal ultrasonography were 68.8%，90.8%， 84.9%， HBS were 95%， 50%， 68.0%， respectively. Conclusion　The common causes of infant cholestasis in BA，idiopathic hepatitis，cytomegalovirus infection，and Citrin protein deficiency. In the infant cholestasis with acholic stools，infracostal liver≥3 cm，serum γ-GT≥300 U/L，cholecyst undiscovered or small in size in abdominal ultrasonography，HBS undiscovered or delayed image of gallbladder or radioactive concentration in bowel，the BA should be suspected.

Select

Diagnosis and treatment value of detecting fecal primary and secondary bile acid in infants with infantile cholestatic hepatopathy LI Meng*，LIU Si-xiang，WANG Ming-ying，et al 2019, 34(4): 295-298.  DOI: 10.19538/j.ek2019040611 Abstract ( )   Objective　To detect the level of fecal primary and secondary bile acids in infants with infantile cholestatic hepatopathy（ICH）and analyze its clinical value. Methods　Thirty infants with ICH were enrolled in this study，who were diagnosed with infantile cholestatic hepatopathy. Thirty infants with good health condition were enrolled as the healthy control group. The fecal samples were collected respectively in the preparatory treatment phase and treatment phase from infants with ICH and from the healthy infants. Bile acids were extracted from infants’ feces and were quantitatively analyzed by liquid chromatography-mass spectroscopy. Results　Among the fecal primary bile acids，the level of cholic acid，chenodeoxycholic and glycochenodeoxycholic acid both in the ICH preparatory treatment group and ICH treatment group was significantly lower than that in the healthy control group（P＜0.016）.The level of fecal cholic acid and chenodeoxycholic acid of ICH treatment group was higher than in the ICH preparatory treatment group（P＜0.016）. Among the fecal secondary bile acids，the level of lithocholic acid both in the ICH preparatory treatment group and ICH treatment group was significantly lower than that in the healthy control group（P＜0.016），and the level of ursodeoxycholic acid in the ICH preparatory treatment group was lower than that in the ICH treatment group and healthy control group（P＜0.016）. Conclusion　In infants with ICH, the changes of fecal primary bile acids and fecal secondary bile acids have their own characteristics at the early stage of treatment, which may be caused by the short-term treatment, the prognosis of the disease itself and the changes of intestinal function, including intestinal bacteria. Clinical attention should be paid to these changes.

Select

Genetic diagnosis of Gilbert syndrome in one case and the literature review MA Tian-jiao，ZHANG Hai-ting，YANG Zhi-liang，et al 2019, 34(4): 299-301.  DOI: 10.19538/j.ek2019040612 Abstract ( )

Select

One case of tricho-rhino-phalangeal syndrome and the literature review WANG Ya-ting，AN Yun-fei 2019, 34(4): 302-304.  DOI: 10.19538/j.ek2019040613 Abstract ( )

Select

Research progress in the role of interleukin-6 and its signaling pathway in central nervous system infection CHEN Xiao-lan，WANG Yang，ZENG Qi-yi 2019, 34(4): 305-308.  DOI: 10.19538/j.ek2019040614 Abstract ( )

Select

Research progress in TSC1and TSC2 genotype and clinical phenotype of tuberous sclerosis complex MEI Dao-qi，FU Na，QIN Jiong 2019, 34(4): 309-314.  DOI: 10.19538/j.ek2019040615 Abstract ( )

Select

Macroamylasemia in one child and the literature review GUO Jiang-bo，LUO You-you 2019, 34(4): 315-316.  DOI: 10.19538/j.ek2019040616 Abstract ( )

Select

A novel frameshift mutation of Chediak-Higashi syndrome and treatment in the accelerated phase XUAN Fan，ZHAO Xiao-qing，MA Fu-tian，et al 2019, 34(4): 317-318.  DOI: 10.19538/j.ek2019040617 Abstract ( )

Select

Construction of pediatrician training system at the primary level HUANG Min*, GUO Gui-mei 2019, 34(4): 319-320.  DOI: 10.19538/j.ek2019040618 Abstract ( )   The pediatrician training system includes four levels of construction mode：the pediatric professional training for general practitioner, general pediatric professional training, pediatric skills training of community in-service physicians and pediatric continuing education for general pedestrians by Pediatric Professional Committee. Standardized and homogeneous training will help to improve children's health service system and change the current shortage of pediatric clinicians at the primary level.

Select

Operation practice of residency program management in pediatric standardized residency training specialty base　 QI Jian-guang， JIANG Yu-wu 2019, 34(4): 321-324.  DOI: 10.19538/j.ek2019040619 Abstract ( )   Strengthening the organization and administration of standardized residency training is essential to ensuring the function and quality of residency training. On the level of secondary discipline of pediatrics，a residency program committee should be established including program director，site coordinators and resident representatives，and so on. The program committee is responsible for the resident admission，training，evaluation and program quality control. Through implementing program director responsibility system，regular meeting of residency program committee and regular seminars，the program management in pediatric standardized residency training specialty base is carried out，so as to ensure the smooth progress of residency training，effectively realizing the clinical teaching professionalization，and ensuring the quality of standardized residency training.

Select

Discussion on the problems and countermeasures of medical education in pediatrics after graduation WANG Ai-hua，JIAO Li-ping，LI Zhe，et al 2019, 34(4): 325-328.  DOI: 10.19538/j.ek2019040620 Abstract ( )   Post-graduation medical education is the only way for pediatric medical graduates to become qualified pediatric clinicians， which play a key role in the process of pediatricians becoming talented. Post-graduation medical education in China has been continuously institutionalized and standardized， and has achieved remarkable progress. However， there are still many problems in the implementation process. The author will carry out in-depth analysis concerning the national policy， base construction， teacher construction and students themselves， propose countermeasures and suggestions for existing problems， and provide ideas for the formation of an efficient and sustainable mechanism for pediatric talent training.