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06 May 2011, Volume 26 Issue 05 Previous Issue    Next Issue

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Research on the correlation between gene polymorphism of surfactant protein A1 and bronchopulmonary dysplasia in neonates. ZHANG Jia，CHANG Li-wen，LI Wen-bin， LIU Wei， ZHOU Yu-rong，ZENG Ling-kong，SHAN Rui 2011, 26(05): 358.  Abstract ( )   To investigate the association between single-nucleotide polymorphisms（SNP） in the pulmonary surfactant protein A1 gene and bronchopulmonary dysplasia in neonates. Methods　From Jul.2008 to Dec.2010 in Tongji Hospital，Tongji Medical College， 38 infants with BPD and 55 normal subjects as control were studied and genetype analysis was determined with the polymerase chain reaction restriction fragment length polymorphism（PCR-RFLP） method. Results　In the BPD group，the distribution of AA50 loucs genetype（P = 0.038） and G/C allele （P = 0.012）differed significantly from the control group.The frequencies of AA219，AA50 and AA19 genetypes and alleles were not different between the BPD infants and normal controls.The frequency of the C/C genetype in AA50 was significantly lower in the infants with BPD than in the normal controls. Conclusion　A gene association exists between SPA1 gene and BPD. In BPD ，possession of the C/C genetype in the AA50 would reduce the the risk of BPD

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Study on serum bone formation markers of female adolescents in different altitude area. WANG Ping*，WANG Zhi-hong，WANG Hong-mei，SUN Tao，XI Huan-jiu. 2011, 26(05): 361.  Abstract ( )   Abstract：Objective　To study the characteristics and differences of serum bone alkaline phosphatase（BAP）， carboxyterminal propeptide of type Ⅰ procollagen （PICP） and osteocalcin（OC） in female adolescents. Methods　A total of 1093 healthy Tibetan-Han adolescents living in Lhasa， Naqu and Jinzhou aged 12～< 19 years were selected，whose height and the levels of BAP， PICP and OC were tested. Results　The levels of BAP， PICP and OC in Lhasa and Naqu were higher than those in Jinzhou. The difference was statistically significant in Lhasa and Jinzhou（ P < 0.01）.The values of serum BAP， PICP and OC reached the peak at 12～< 13 years in all groups. Levels of markers declined with increase of age after peak （P < 0.05）， but decreasing trend was flat in Jinzhou. Positive correlativity was observed between BAP， PICP，OC and height（r = 0.56， 0.48， 0.43，P < 0.01）. Conclusion　Change characteristics of serum BAP，PICP and OC is consistent with age in female adolescent in different altitude area， but the levels are higher in Tibetan Plateau than that  in Han Plain. This reveals that in Tibetan Plateau the normal reference values should be established for the bone biomarkers. We should further improve the living conditions of Plateau girls so as to promote its growth potentiality.

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Correlation of obesity indexes with blood pressure and blood lipid of children and adolescents.　　 ZHANG Zhi-wei，XU Dong-jiang，ZU Shu-yu，HAN Shao-mei，XU Cheng-li，ZHU Guang-jin. 2011, 26(05): 364.  Abstract ( )   To investigate the relationship between body mass index（BMI），waist circumference（WC），waist haunch ratio（WHR），waist height ratio（WHtR）and metabolic factors of Tibetan children in Sichuan province. Methods 　Totally 818 Tibetan children （aged from 10 to 17）in Songpan，Sichuan province with complete information were selected by stratified multi-stage cluster random sampling method in October，2007. The systolic blood pressure（SBP），diastolic blood pressure（DBP），serum concentration of cholesterol（TC）， triglycerides （TG），high-density lipoprotein cholesterol（HDL-C）and low-density lipoprotein cholesterol（LDL-C）were measured and the correlationships among them were analyzed. Results　The incidence of overweight and obesity in girls（12.78%）was much higher than that of boys（3.30%）.The level of blood pressure and blood lipid were of significant difference among the normal group and overweight/obesity group both in girls and in boys.Controlling for sex and age，there was a positive correlation between BMI，WC and SBP，DBP.Also，there was correlation between the blood lipid levels and obesity indicators. Conclusion　The levels of BMI，WC，WHR，WHtR，blood pressure and blood lipid of Tibetan children in Sichuan are variable in different sexes and age groups.Therefore， monitoring of the BMI，WC，WhR and WhtR plays an important role in controlling and maintaining the blood pressure and lipid.

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Different clinical feature analysis of solid-pseudopapillary tumor of pancreas between children and adults.　　 MA Wei，WANG Jia-xiang，YANG He-ying，ZHANG Da. 2011, 26(05): 369.  Abstract ( )   To analyze the clinical features of solid-pseudopapillary tumor of pancreas （SPTP） between children and adults，and determine the predictive features of malignant potential. Methods　Besides 10 patients we received from January 2006 to June 2010，386 patients were collected by retrieveing China Wanfang Data during October 2010，and all the information was analyzed retrospectively. Results 　Among 396 patients，45 patients were children and 351 patients were adults. A palpable mass （46.7%） and abdominal pain （31.1%） were the most common presenting symptom in children，while in adults，the tumor was always found by health examination （37.9%） or abdominal discomfort （27.4%）. The mean tumor size in children was larger than in adults（P < 0.05）. In children，the tumor was located in the head or neck of the pancreas （57.8%），while in adults，in the body or tail （65.2%） （P = 0.003）. Univariate analysis indicated that the difference of portal vein invasion and metastasis between benign and malignant of SPTP was significant both in children and adults. Conclusion　SPTP has different clinical features in children and adults. Portal vein invasion and metastasis are probably the potential malignant presentations. Complete removal and long term follow-up are the best choice.

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Clinical observation on glucose and lipid metabolism in Turner syndrome children with growth hormone treatment.　　 LIU Ying-ke，ZHANG Zhi-xin，ZHAO Qiu-ling，SU Hui-min，ZHANG Qiong. 2011, 26(05): 373.  Abstract ( )   To observe the glucose and lipid metabolism changes after recombinant human growth hormone treatment in the Turner syndrome patients，and provide safety data for clinical therapy. Methods　Twenty-eight Turner syndrome children were selected who were definitely diagnosed with Turner syndrome between July 2007 and June 2010 in China-Japan Friendship Hospital. Each took the body fat checking ，lipid level detection and glucose tolerance test before and after 6 months of rhGH therapy. The human growth hormone was given through subcutaneous injection. Use the two paired t-test to compare the data before and after the treatment in glucose and lipid metabolism. Results 　There were 4 abnormal karyotypes in the 28 cases. In the measurement of body fat，there were significant differences （P <0.05） in the fat percentage，but no significant differences （P > 0.05） in the fat mass. In the lipid level detection，there were significant differences （P < 0.05） in HDL-C and LDL-C after GH intervention. The TG and CHO improved a little，but there were no significant differences （P > 0.05） between before and after the treatment. In the OGTT test，5 IGT cases were founded. This situation was not changed after 6 months of treatment. There was no significant difference in the HOMA-IR （1.63 ± 0.45 vs 1.58 ± 0.44） during the GH intervention. Conclusion　There is a high risk of glucose and lipid metabolism disorder in the TS children. After 6 months of recombinant human growth hormone intervention， the lipid metabolism can be improved，and the glucose metabolism can be aggravated. It is necessary to monitor the patient’s glucose and lipid metabolism further.

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Study on the deficiency of SHOX gene and its correlation with corresponding phenotypes of ISS.　　 XIE Fang，ZHU Min，CAO Yan-li，XIONG Feng . 2011, 26(05): 377.  Abstract ( )   To study the deficiency and mutation of short stature homeobox containing （SHOX） gene and the relationship betweengenotypes and phenotypes. Methods　The variations in gene SHOX and the pseudoautosomal region （PARI） of the sex chromosomes in 354 individuals in the Children's Hospital，Chongqing Medical University with idiopathic short stature （ISS） were tested，and the results were compared with 200 normal height controls，using microsatellites and direct sequencing. Results　The prevalence of SHOX deficiency in patients with idiopathic short stature was 10.5%，among which 3 mutations（8.1%）、32 deletions（86.5%） and 2 deletions（5.4%） of CNE9 were found. Compared with the normal，certain dysmorphics had been found，such as BMI，upper segment/height，et al. Conclusion　Certain correlations between genotypes and corresponding phenotypes haved been found in patients with SHOX deficiency.

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Analysis of the therapeutic effects of mechanical ventilation with different tidal volume on the children with severe pneumonia.　　 QIAN Min， GUO Shi-jie， YAN Chao-ying. 2011, 26(05): 382.  Abstract ( )   To observe the therapeutic effects of mechanical ventilation with different tidal volume on the children with severe pneumonia. Methods　Fifty child patients with severe pneumonia were given mechanical ventilation. These patients were randomized into two groups： one group used low tidal volume （6～8 mL/kg），while the other group used conventional tidal volume （10～12  L/kg）. Observe the changes of artery blood gas analysis after ventilation， time of mechanical ventilation and mortality. Follow up the respiratory system symptoms of survival patients. Results　After 24 hours of mechanical ventilation， the PaO2 and P/F in conventional tidal volume group were higher than in low tidal volume group； PaCO2 and pH in conventional tidal volume group were lower than in low tidal volume group. The duration of mechanical ventilation in conventional tidal volume group was （5.4±1.8）d， while in low tidal volume group it was （9.5±1.7） d. The mortality of conventional tidal volume group was 16%，while in low tidal volume group it was 36%. Morbidity of survival patients with recurrent respiratory tract infection in conventional tidal volume group was 28.6%，while in low tidal volume group it was 31.3%. Conclusion 　Therapeutic effect of mechanical ventilation with conventional tidal volume is better than low tidal volume in the children with severe pneumonia.