Chinese Journal of Practical Pediatrics

Chinese Journal of Practical Pediatrics ›› 2024, Vol. 39 ›› Issue (12): 906-911.DOI: 10.19538/j.ek2024120605

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Pay attention to the bone health status of patients with disorders of sex development

  

  1. Department of Endocrinology，Genetics and Metabolism，Beijing Children’s Hospital，Capital Medical University，National Center for Children’s Health，Beijing  100045，China
  • Online:2024-12-06 Published:2025-02-24

重视性发育异常儿童的骨骼健康状况

  

  1. 国家儿童医学中心（北京）  首都医科大学附属北京儿童医院内分泌遗传代谢科，北京  100045
  • 通讯作者: 巩纯秀，电子信箱：chunxiugong@sina.com
  • 基金资助:
    首都临床诊疗技术研究及转化应用项目（Z201100005520061）；北京市医院管理中心“青苗”计划项目（QML20201205）；金磊儿科内分泌中青年医师成长科研基金项目（PEGRF202011034）

Abstract: Disorders of sex development （DSD） is a collective term for a large group of genetically heterogeneous disorders affecting multiple systems in human body. Childhood is a critical period for bone growth and development and has a significant impact on bone health in adulthood. In this paper， the bone health status of DSD patients with different etiologies was expounded. The problem of bone mass loss was common in DSD patients， and it was suggested that clinical attention should be paid to the bone health status of DSD patients.

Key words: disorders of sex development, bone health, bone mineral density

摘要： 性发育异常（disorders of sex development，DSD）是一大类遗传异质性疾病的总称，影响人体多个系统。儿童期是骨骼生长和发育的关键时期，对成年后的骨骼健康具有重要影响。文章就不同病因DSD患儿的骨骼健康状况进行阐述，DSD患儿普遍存在骨量减低问题，提出临床上要重视DSD患儿的骨骼健康状况。

关键词: 性发育异常, 骨骼健康, 骨密度