Abstract: Osteogenesis imperfecta is a group of rare skeletal diseases with clinical heterogeneity and different clinical severity. Due to the distribution of type I collagen，osteogenesis imperfecta often involves multiple systems as well requiring multidisciplinary treatments. Understanding the common clinical manifestations of osteogenesis imperfecta，mastering the principles of treatment，and carrying out multidisciplinary management are essential to improving the quality of life of patients with osteogenesis imperfecta.

Key words: osteogenesis imperfecta, multidisciplinary management, type Ⅰ collagen

摘要： 成骨不全是一组临床异质性的罕见骨病，临床表现轻重不一。由于I型胶原分布广泛，成骨不全常累及多系统，因而需要多学科合作。了解成骨不全常见的临床表现，掌握治疗原则，开展多学科管理，对提高成骨不全患儿的生活质量十分重要。

关键词: 成骨不全, 多学科管理, Ⅰ型胶原