Abstract: Neonatal septicemia is a common severe infectious disease，which progresses rapidly and is an important cause of death in the neonatal period. Soluble form of Triggering Receptors Expressed on Myeloid cell-1 （sTREM-1） is a soluble subtype of Triggering Receptors Expressed on Myeloid cell-1 （TREM-1），which is highly expressed in inflammatory response. It can activate cell pathways and amplify inflammatory response by collaborating with multiple cell receptors. Sufficient evidence has confirmed that sTREM-1 plays an important role in the early recognition，disease progression and prognosis evaluation of neonatal septicemia. This article will review the biological characteristics，signal pathway and role of sTREM-1 in neonatal septicemia.

Key words: soluble form of triggering receptors expressed on myeloid cell-1 （sTREM-1）, neonatal septicemia, biomarker

摘要： 新生儿败血症是新生儿期常见的重症感染性疾病，其病情进展迅速，是新生儿期死亡的重要原因。可溶性髓样细胞触发受体-1（soluble form of triggering receptors expressed on myeloid cell-1，sTREM-1）是髓样细胞触发受体-1（triggering receptors expressed on myeloid cell-1，TREM-1）的可溶性亚型，在炎症反应中高度表达，与多种细胞受体协同作用可激活细胞通路及放大炎症反应。大量研究证实sTREM-1在新生儿败血症的早期识别、病情进展及预后评估方面具有重要作用。该文对sTREM-1的生物学特性、信号通路及在新生儿败血症中的作用进行综述。

关键词: 可溶性髓样细胞触发受体-1, 新生儿败血症, 生物标志物