Abstract:

Objective    To approach the diagnosis and treatment of eosinphilic gastroenteritis in children. Methods    In 12 cases of children with eosinophilic gastroenteritis in Nanjing Children's Hospital Affiliated to Nanjing Medical University from May 2009 to Nov.2011，the clinical manifestations，laboratory data，endoscopic and pathological findings and treatment were collected and analyzed. Results    In the 12 patients，mucosal type was present in 8 cases，muscle-type in 1 case，and serous type in 3 cases. Most of the pediatric eosinophilic gastroenteritis had no specific clinical manifestations. From direct endoscopic vision，edema and erosion were the main performance of gastrointestinal mucosa. Histopathologic examination revealed that there was dense infiltration in gastrointestinal mucosa lamina propria by eosinophils. The effects of dietetic and antianaphylactic treatments were good. Conclusion    The clinical manifestations of pediatric eosinophilic gastroenteritis are various and nonspecific. The dietetic and antianaphylactic treatments have obvious therapeutic effect . About 1 to 2 weeks of glucocorticoids therapy can rapidly alleviate the symptoms，and it continues for 3 months by reducing the dosage gradually.

Key words: children, eosinophilic gastroenteritis, glucocorticoids, dieteic treatments, antianaphylactic treatments

摘要：

目的    探讨小儿嗜酸细胞性胃肠炎诊断和治疗。方法    2009年5 月至2011年11月南京医科大学附属南京儿童医院收集12例小儿嗜酸细胞性胃肠炎患儿的临床表现、实验室资料、内镜及病理检查结果及治疗并进行分析。结果    12例患者中黏膜型8例、肌型1例，浆膜型3例；内镜下胃肠黏膜呈水肿、糜烂为主，病理检查胃肠黏膜固有层有嗜酸细胞浸润。经治疗效果较好。结论    小儿嗜酸细胞性胃肠炎临床表现存在多样性，无特异性，饮食疗法和抗过敏治疗效果良好。糖皮质激素治疗1~2周内可迅速缓解症状，逐渐递减剂量维持，直至3个月内停药。

关键词: 儿童, 嗜酸细胞性胃肠炎, 糖皮质激素, 饮食疗法, 抗过敏治疗