Abstract:

Objective　To investigate the association of mast cells（MC）desity and their activation states with electrogastrography（EGG） in pediatric functional dyspepsia（FD）. Methods　From Jan.2007 to Jan.2010，40 consecutive patients from pediatric clinic in the First Affliatied Hospital of Sun Yat-sen University diagosed with FD according to Rome Ⅲ criteria were recruited in our study. After an antral biopsy was obtained for calculating the amount and degranulation index of MC，the EGG was recorded for all patients. Results　（1）With a mean of（65.7 ± 23.9）%，MC degranulation index was > 50% in 82.5% patients.（2）MC density increased in patients with abnormal EGG（P < 0.05），compared with the normal EGG.（3）The percentage of preprandial normal slow waves was decreased in patients with increasing mean MC density（P = 0.005） and in patients with increasing peak MC density（P = 0.01）. （4） MC degranulation index wasn't correlated with EGG；（5）Increasing mean MC density and increasing peak MC was associated with a decreased percentage of preprandial normal slow waves（P < 0.05）. Conclusion　There is a negative correlation between EGG abnormalities and elevated MC density in pediatric patients with FD. MC may mediate the generation and development of FD through influencing EGG.

Key words: functional dyspepsia, children, gastric mucosa, mast cell, electrogastrography

摘要：

目的　探讨功能性消化不良（FD）患儿胃黏膜肥大细胞（MC）的密度及其活化状态与胃电图之间的相互关系。方法　按罗马Ⅲ标准选择2007年1月至2010年1月于中山大学附属第一医院就诊的FD患儿40例，取胃窦黏膜1块，通过免疫组化法检测MC数及其脱颗粒数，然后行胃电图检测。结果　（1）FD患儿的胃黏膜MC脱颗粒指数均值为（65.7 ± 23.9）%，其中 > 50%者占82.5%；（2）与胃电节律正常组相比，胃电节律异常组的MC密度显著升高（P < 0.05）；（3）与MC平均密度正常组相比，MC平均密度异常组在餐前正常慢波百分比明显降低（P = 0.005）；与MC峰密度正常组相比，MC峰密度异常组的餐前正常慢波百分比明显降低（P = 0.01）；（4）MC脱颗粒指数与胃电无明显关系；（5）餐前正常慢波百分比与MC平均密度及MC峰密度呈负相关（P < 0.05）。结论　FD患儿的胃电异常与MC密度升高有关，MC可能通过影响胃电介导了儿童FD的发生和发展。

关键词: 功能性消化不良, 儿童, 胃黏膜, 肥大细胞, 胃电图