Abstract:

To study the changes of plasma homocysteine， serum lipid in simple obese children，and the relations between plasma homocysteine，serum lipid and cardiovascular and cerebrovascular diseases， and to provide a new path to prevent and cure the simple obesity in children and cardiovascular and cerebrovascular diseases in adulthood. Methods　Thirty-four cases of simple obese children were collected in the First Affiliated Hospital of Dalian Medical University from December 2008 to December 2009，25 cases of healthy children were selected in our study in the same period. Liver morphology was detected by Color Doppler ultrasound. Venous blood was taken after 12 hours fasting. The levels of total plasm homocysteine（HCY）， cholesterol（TC），triglyceride（TG）， high-density lipoprotein（HDL-Ch），low-density lipoprotein（LDL-Ch） and plasma lipoprotein（a）［ LP（a）］ were determined. Results　Liver morphology changed in 18 cases of simple obese children，while only 1 in healthy children. TC，TG and LDL-Ch in simple obese children were significantly higher than those of control group，the difference being statistically significant（P < 0.05）. Serum HDL-Ch and LP（a） between the two groups had no obvious difference（P > 0.05）. The levels of plasma HCY in the simple obese children［（10.91±2.57）μmol/L］ was significantly higher than control group ［（5.13±1.12）μmol/L］ （P < 0.05）. The level of plasma HCY and blood lipid had no obvious relevance. Conclusion　Simple obese children are more susceptible to suffer from fatty liver than healthy children；it is closely related to the lipid metabolism. The level of HCY is significantly higher in simple obese children， which has no obvious relevance to blood lipid，and it is one of independent risk factors of cardiovascular and cerebrovascular diseases.

Key words: simple obesity, homocysteine, blood lipid, fatty liver

摘要：

探讨单纯性肥胖儿童血浆同型半胱氨酸（HCY）、血脂的变化及其与心脑血管疾病的关系，为儿童单纯性肥胖及成年期心脑血管疾病的防治提供新的思路。方法　收集2008年12月至2009年12月大连医科大学附属第一医院34例单纯性肥胖患儿及25例同期健康体检儿童，利用彩色多普勒超声探查肝脏形态结构；同时取禁食12 h以上的静脉血，检测血浆HCY、血浆总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白（HDL-Ch）、低密度脂蛋白（LDL-Ch）及血浆脂蛋白（α）［LP（α）］。结果　肥胖组18例出现肝脏形态改变，对照组中仅1例；肥胖组血浆TC、TG、LDL-Ch明显高于对照组，差异有统计学意义（P均 < 0.05）；HDL -Ch、LP（α）与对照组比较，差异无统计学意义（P > 0.05）；肥胖组血浆HCY为（10.91±2.57）μmol/L，对照组为（5.13±1.12）μmol/L，前者较后者明显增高（P < 0.05）；血浆HCY与血脂水平间无明显相关性。结论　单纯性肥胖儿童较健康儿童更易患有脂肪肝或脂肪肝倾向，其发生与患儿脂质代谢异常密切相关；单纯性肥胖儿童血浆HCY明显增高，且HCY与血脂水平无相关性，是心脑血管疾病的独立危险因素之一。

关键词: 单纯性肥胖, 同型半胱氨酸, 血脂, 脂肪肝