Abstract:

Department of Pediatrics，Beijing Tongren Hospital affiliated to Capital University，Beijing 100730，China
Abstract：Objectives　To evaluate the effects of CTV （carboplatin，Teniposide Vincristine） chemotherapy and intrathecal chemotherapy in

children with tumor cell of retinoblastoma in cerebrospinal fluid. Methods　Totally 256 cases who were clinically diagnosed with

retinoblastoma in our hospital were studied， 6 of them who had tumor cells in their cerebrospinal fluid before treatment were given 6～9

cycles of CTV（Carboplatine、Teniposide and Vincristine）chemotherapy and 8～10 times of intrathecal chemotherapy； meanwhile， focal therapy

was performed. Follow-up was between 12 to 20 months. Results　All patients had completed the therapy， up to now condition stable； recheck

the cerebrospinal fluid didn't show the tumor cell. Conclusion　System chemotherapy together with intrathecal chemotherapy is effective for

children with tumor cell of retinoblastoma found in cerebrospinal fluid. However， more patients with longer follow-up are needed to confirm

these results.

Key words: retinoblastoma；cerebrospinal fluid；intrathecal injection；chemotherapy；children

摘要：

观察全身应用卡铂、替尼泊苷和长春新碱（CTV）方案化疗加鞘内注射治疗脑脊液细胞学检查肿瘤细胞阳性的视网膜母细胞瘤（RB）患儿的疗效。方法　6例患儿资料来自首都医科大学附属北京同仁医院2006年11月至2008年7月临床确诊为RB且治疗前行脑脊液细胞学检查发现肿瘤细胞者，对其进行6～9次CTV方案化疗加8～10次鞘内注射治疗，同时结合局部治疗，随访12～20个月，观察疗效。结果　6例患儿均完成治疗，病情稳定，复查脑脊液细胞学检查均未发现肿瘤细胞，无复发及死亡。结论　全身化疗加鞘内注射是对RB颅内转移有效的治疗方法，由于观察时间较短，长期疗效尚须行观察。

关键词: 视网膜母细胞瘤, 脑脊液, 鞘内注射, 化疗, 儿童