Abstract:

To improve the level of recognization， diagnosis and treatment of hypoparathyroidism. Methods  　The clinical data of

10 patients with hypoparathyroidism， diagnosed between April 2002 and April 2009 in Shenzhen Children's Hospital， was retrospectively

analyzed. Results　In the 5 cases of idiopathic hypoparathyroidism （ IHP ）， and the other 5 cases of pseudohypoparathyroidism （ PHP ），

the blood calcium decreased， while serum inorganic phosphorus increased（except one case was normal）. The PTH decreased in the cases of IHP

， and increased in the cases of PHP. With the treatment of calcium and Vitamin D， the symptoms were controlled， and the blood biochemistry

returned to normal. Those who were identified during babyhood achieved good effect， without disturbances on mentality and cognition.

Conclusion　Patients， who have epilepsy or repeated tetany， should be detected blood calcium， phosphorus， PTH and brain CT. The treatment

of calcium and Vitamin D can control the symptoms. The blood calcium， phosphorus and 24-hour urinary calcium should be checked during

treatment.

Key words:  hypoparathyroidism；blood calcium ；blood phosphorus

摘要：

提高对甲状旁腺机能减退症（HP）的认识，总结其诊断及治疗经验。方法　对深圳市儿童医院2002年4月至2009年4月来诊的10例HP患儿临床资料进行回顾性分析。结果　特发性甲状旁腺机能减退症（IHP）5例，假性甲状旁腺机能减退症 （PHP） 5例；全部病例均存在低血钙、高血磷（除1例血磷正常），IHP甲状旁腺激素（PTH）水平低下，PHP则PTH水平高；经补钙及维生素D治疗后，临床症状均消失，血生化基本恢复正常；婴儿期即诊断明确者，疗效好，无智力及认知功能障碍。结论　对癫痫及反复手足搐搦者，应及时行血钙、血磷、血清PTH测定，并行头颅CT检查。用钙剂及维生素D可以控制症状。治疗期间应定期复查血钙、血磷及24 h尿钙。

关键词: 甲状旁腺机能减退症, 血钙, 血磷