Abstract:

To investigate the relationship between family history and dyslipidemia in children. Methods　This study was

performed by research group on adult chronic diseases prevention and therapy in children.Cluster randomized sampling in a transecting

epidemiological survey of children aged 6 to 18 years in Beijing area were used； 9665 boys and 9641 girls were virtually included in the

study. They were divided into four subgroups， including school boys， school girls， adolescent boys and adolescent girls. Parent history of

metabolic syndrome and premature cardiovascular diseases were defined as first degree family history， grandparent or/and uncle/aunt history

of metabolic syndrome and cardiovascular diseases were defined as second degree family history， while others were defined as without family

history. Fasting capillary blood total cholesterol （TC） and triglyceride （TG） levels were detected. Results　TC and TG levels of school

boys and adolescent boys with first degree family history were all much higher than boys without family history（4.07±0.41）mmo/L vs（4.00±

0.33） mmo/L，P < 0.05； TG of adolescent girls was significantly higher than girls without family history （1.26±0.75） mmo/L vs （1.20±

0.66 ） mmo/L，P < 0.05. TC and TG levels of school boys and adolescent boys with second degree family history were all much higher than boys

without family history（P < 0.05）； TC levels of school girls and adolescent girls with second degree family history were all much higher

than girls without family history（P < 0.05）. Possibility of dyslipidemia of  school and adolescent boys and school girls with first degree

family history was much higher than those with non- first degree family history（11.6 %vs 7.1%， 11.2 %vs 8.4%， 10.8% vs 8.0%，P < 0.05）.

Possibility of dyslipidemia of adolescent boys and girls with second degree family history were significantly higher than those without

family history （10.3% vs 7.8%，14.7% vs 11.8%，P < 0.05）. Conclusion　The lipid level of children differed significantly according to

different background of family history. Not only first degree family history but also second degree family history ought to be considered in

screening of dyslipidemia in children.

Key words: children；dyslipidemia；family history

摘要：

探讨家族史与儿童血脂水平的关系。方法　2004年4月至10月“营养转型期儿童、成人慢性病综合性防治研究”课题组采用整群抽样方法对北京地区6～18岁儿童青少年进行横断面流行病学调查。有效调查对象19306名，其中男9665名，女9641名；按年龄及性别分为男性学龄期组、青春期组，女性学龄期组、青春期组。根据家族史背景分为无家族史、有一级家族史、有二级家族史。对其空腹末梢血总胆固醇（TC）、三酰甘油（甘油三酯TG）进行检测。结果　有一级家族史者，各年龄段男童组TC及TG水平均显著高于无家族史者（P < 0.05），学龄期女性儿童组TC显著高于无家族史者[（4.07±0.41） mmo/L 、 （4.00±0.33） mmo/L，P < 0.05]，青春期女性儿童组TG显著高于无家族史者[（1.26±0.75） mmo/L、（1.20±0.66） mmo/L，P < 0.05]；有二级家族史者，各年龄阶段男性儿童组TC及TG均显著高于无家族史者（P < 0.05），各年龄组女性儿童TC均显著高于无家族史者（P < 0.05）。将肥胖作为混杂因素行协方差分析后，有不同家族史背景的各年龄性别分组儿童TC水平差异仍有统计学意义（P < 0.05）。学龄期男性儿童组、青春期男性儿童组及学龄期女性儿童组有一级家族史者血脂紊乱的发生率均显著高于非一级家族史者（11.6 %、7.1%， 11.2 %、 8.4%， 10.8%、8.0%，P < 0.05），有二级家族史青春期男性儿童组及青春期女性儿童组血脂紊乱的发生率显著高于无家族史者（10.3%、7.8%，14.7%、11.8%，P < 0.05）。结论　不同家族史背景儿童血脂水平差异有统计学意义，一级及二级家族史在儿童血脂紊乱筛查中具有一定意义。

关键词: 儿童；血脂紊乱；家族史