Abstract: Objective　To investigate the relationship between the levels of plasma leptin、neuropeptide Y and motilin and gastric emptying in children with anorexia. Methods　From September 2007 to August 2008 in Liwan Hospital Affiliated Hospital of Guangzhou Medical College， the levels of plasma neuropeptide Y and motilin were measured by immunoradioassay and the level of leptin was measured by ELISA in 40 anorectics children and 30 healthy children. All of them received gastric emptying test. Results The levels of plasma leptin、 neuropeptide Y and motilin in anorectics children were significantly lower than those of healthy children （P < 0.01）. Gastric emptying test showed the rate of gastric antrum remaing in anorectics children was higher than that of healthy children in postprandial 60 mins ， 90 mins and 120 mins respectively. The rate of gastric antrum remaing in postprandial 30 mins was similar in two groups. Conclusion　The decreased level of plasma inhibiting factors leptin does not lead to anorectics ； the decreased level of plasma aperitive factors neuropeptide Y can lead to motilin decrease ； gastric emptying disturbance can increase gastric retention.The feedback control mechanism of plasma inhibiting factors leptin and aperitive factors neuropeptide Y might be disturbed.

Key words: motilin, gastric emptying , leptin, neuropeptide Y

摘要： 目的　探讨厌食症患儿血浆瘦素、神经肽Y、胃动素与胃排空的关系。方法　2007年9月至2008年8月在广州医学院荔湾医院门诊就诊符合厌食症诊断标准的患儿40例作为厌食组，采用放免法检测血浆神经肽Y（Neuropeptide Y，NPY）、胃动素（Motilin）及用ELISA法检测血浆瘦素（Leptin，LP），并进行B超胃液体排空功能试验。同时以30名健康儿童作为对照组行相应检查。结果　厌食组血浆LP水平低于对照组，NPY、胃动素水平也较对照组明显降低，差异有统计学意义（P < 0.01）。厌食组胃液体排空功能试验示，餐后60、90和120 min时胃窦残留率均明显高于对照组，差异有统计学意义（P < 0.01），餐后30 min胃窦残留率与对照组比较，差异无统计学意义。结论　厌食症患儿血浆抑制食欲因子LP降低不是导致厌食的主要原因；血浆食欲促进因子NPY降低导致胃动素不足，胃排空障碍，胃潴留增加；厌食症患儿血浆LP与NPY之间的反馈调节机制可能存在障碍。

关键词: 厌食症, 瘦素, 神经肽Y, 胃动素, 胃排空