Abstract: Objective　To compare exercise with hypertonic saline challenges in children with asthma so as to choose a safe and suitable empirical method to detect the airway reactivity in children with asthma. Methods　Thirty-four patients in children with asthma （5 to 13 years） were selected. The exercise challenge tests and hypertonic saline challenge tests were performed on the same patients within certain intervals. Results　The hypertonic saline challenge test was more sensitive than exercise challenge test （P < 0.01）. Conclusion　The sensitivity of hypertonic saline provocative test is superior to exercise challenge in children with asthma， and the method is simple， safe and with fewer side effects.

Key words: exercise , bronchial provocation test, hypertonic saline

摘要： 目的　研究高渗盐水激发试验及运动激发试验在哮喘儿童的临床应用，旨在寻求更适合哮喘儿童的气道反应性检测的方法。方法　收集中国医科大学附属 盛京医院2007年5月至2008年6月符合儿童支气管哮喘防治常规诊断　标准的哮喘缓解期患儿34例，年龄5～13岁，在规定时间内先后做气道高渗盐水激发试验和运 动激发试验。结果　同一哮喘患儿高渗盐水激发试验的敏感性显著高于运动激发试验（P < 0.01）。结论　高渗盐水激发试验的敏感性和特异性高于运动激发试 验，而且设备低廉，方法简单、易配合，安全，副反应少，尤其适用于在哮喘治疗期间动态观察儿童气道的反应性，对指导药物治疗有重要价值。

关键词: 哮喘, 儿童, 支气管激发试验, 高渗盐水, 运动