Abstract: Objective　To explore the pathogenic role of serum cytokines and its clinical significance in Tourette’s Syndrome （TS）. Methods 　Serum IL-6， IL-8 and TNF-αwere determined by ELISA in 58 children with TS and 30 healthy subjects. Those TS children whose immune functions were abnormal were divided randomly into two groups and were treated respectively by using simple immunomodulator and by using dopaminergic receptor antagonists while using immunomodulator. Results　（1）Compared with control， the levels of serum IL-6 and IL-8 in TS group were depressed（P < 0.01）and TNF-α were increased（P < 0.01）. （2）The levels of serum IL-6，IL-8 and TNF-αin TS group after treatment were increased more than those of before treatment（P <0.01and P <0.05）；（3） After 8W of treatment， the level of IL-8 was higher in the group treated by simple immunomodulator than that by dopaminergic receptor antagonists while using immunomodulator（P <0.05）， the curative effect between the two groups having no significant difference. （4） There were significant positive correlations among IL-6， IL-8 and TNF-α（P <0.01）. Conclusion　There is abnormal expression of cytokine in children with Tourette’s syndrome. The disequilibrium of cytokine network may play a role in the pathomechanisms of TS. Simple immunotherapy may be effective in treating TS whose immune functions are abnormal.

Key words: cytokine, treatment , children

摘要： 目的　探讨细胞因子在Tourette综合征（TS）发病中的临床意义。方法　采用酶联免疫吸附（ELISA）法检测2005年5月至2005年12月首都儿科研究所就诊 的58例TS患儿和30名对照组健康儿童的血清细胞因子，包括白细胞介素（IL）-6、IL-8和肿瘤坏死因子（TNF）-α水平。将细胞免疫异常者随机分为两组，分别 给予免疫调节剂或免疫调节剂合用多巴胺受体阻滞剂治疗。结果　与对照组比较，TS组治疗前血清IL-6和IL-8水平显著降低，TNF-α水平显著增高（P均 < 0.01 ）；TS患儿治疗后血清IL-6、IL-8和TNF-α水平均较治疗前明显增高（P < 0.01，P < 0.05）；治疗8周末，单纯采用免疫调节剂治疗组IL-8水平高于联合治疗组 （P < 0.05），两组间疗效差异无统计学意义（P > 0.05）；TS患儿IL-6、IL-8和TNF-α间存在显著正相关（P 均 < 0.01）。 结论　 TS患儿存在细胞因子的 异常表达，单纯免疫调节治疗对免疫异常的TS有一定疗效。

关键词: Tourette综合征, 儿童, 细胞因子