Abstract:

Intractable epilepsy often requires a combination of drugs. To reduce the seizures in children， minimize the side effects of drugs， and improve the patient’s quality of life， it is very important to be familiar with the main mechanisms and pharmacokinetics of antiepileptic drugs， and correctly choose drugs according to the types of seizure and syndrome. Also every time to add a new drug， it must consider the dosage and speed of titration of the drug to avoid serious adverse effects.

Key words: intractable epilepsy/refractory epilepsy；anti- , epileptic drugs（AEDs）；combination therapy

摘要：

难治性癫痫往往需要多种药物联合治疗。因此，熟悉抗癫痫药物的作用机制和药代动力学主要特点， 按照发作类型和综合征进行选药， 注意加量速度和剂量， 避免严重药物不良反应， 对于最大限度减少患儿发作、 改善认知功能、 减少不良反应、 提高患儿生活质量， 有着非常重要的意义。

关键词: 难治性癫痫, 抗癫痫药物, 联合治疗